Results 91 to 100 of about 28,160 (215)

Urinary markers in heart failure – types, timing and thresholds. European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, EarlyView.
Pathophysiologic mechanisms of heart failure (HF) (i.e. renin–angiotensin–aldosterone system [RAAS], congestion, and inflammation), together with patient‐related factors such as diabetes, hypertension, and chronic kidney disease (CKD), contribute to kidney function decline and glomerular or tubular injury.
Masatake Kobayashi, Biykem Bozkurt, Peder Langeland Myhre, Juan Carlos Lopez Azor, Mateusz Guzik, Gracjan Iwanek, Guillaume Baudry, Marta Cobo‐Marcos, Òscar Miró, Jeroen Dauw, Piotr Ponikowski, Wilfried Mullens, Alberto Palazzuoli, Marco Metra, Jan Biegus   +14 more
wiley   +1 more source

A functional role for spontaneously occurring natural anti‐transthyretin antibodies from patients with transthyretin cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Ortal Tuvali, Michael Fassler, Sorel Goland, Clara Benaim, Sara Shimoni, Jacob George   +5 more
wiley   +1 more source

Efficacy and safety of vutrisiran in transthyretin amyloid cardiomyopathy across the age spectrum: The HELIOS‐B trial

European Journal of Heart Failure, EarlyView.
Summary of the HELIOS‐B trial design. Right: Forest (top) and spline (bottom) plots demonstrating the effect of vutrisiran versus placebo on clinical outcomes across age groups in HELIOS‐B. Age‐stratified outcomes with vutrisiran in transthyretin amyloid cardiomyopathy.
Awais Sheikh, Zi Michael Miao, Brian Claggett, Pablo Garcia‐Pavia, Francesco Cappelli, Emre Aldinc, Julian Gillmore, Scott D. Solomon, Marianna Fontana   +8 more
wiley   +1 more source

Cardiac amyloidosis in a Swiss autopsy cohort – distribution and clinical relevance

Swiss Medical Weekly
AIMS: Cardiac amyloidosis (CA) characterised by myocardial amyloid accumulation is likely underdiagnosed. The distribution and extent of myocardial amyloid deposits remain unclear.
Albert Baschong, Sara Ersözlü, Frank Ruschitzka, Andreas J. Flammer, Christoph A. Meier, Zsuzsanna Varga, Holger Moch, Umberto Maccio   +7 more
doaj   +1 more source

Risk stratification in transthyretin-related cardiac amyloidosis [PDF]

, 2023
Riccardo Scirpa, Edoardo Cittadini, Lorenzo Mazzocchi, Giacomo Tini, Matteo Sclafani, Domitilla Russo, Andrea Imperatrice, Alessandro Tropea, Camillo Autore, Beatrice Musumeci   +9 more
openalex   +1 more source

Comparison of cardiac diffusion MRI using multiple prospective respiratory motion correction techniques

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose A novel prospective motion correction control system with slice tracking (MNav‐CoS) was compared with three other prospective respiratory motion correction techniques in performing free‐breathing cardiovascular diffusion tensor imaging (cDTI) acquisitions. Methods Ten healthy volunteers underwent cDTI using an M2SE sequence.
Stephen Jermy, Aaron Hess, Zakariye Ashkir, Betty Raman, Ian Burger, Francesca Little, Ntobeko Ntusi, Ernesta Meintjes, Elizabeth M. Tunnicliffe   +8 more
wiley   +1 more source

Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States

ClinicoEconomics and Outcomes Research, 2019
Tiffany P Quock,1 Tingjian Yan,2 Ryan Tieu,2 Anita D’Souza,3 Michael S Broder21Medical Affairs, Prothena Biosciences Inc, South San Francisco, CA, USA; 2Health Services Research, Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA;
Quock TP, Yan T, Tieu R, D'Souza A, Broder MS   +4 more
doaj  

Bidirectional crusher gradient method to estimate the labeling efficiency of pseudo‐continuous arterial spin labeling MRI in mice

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To develop an experimental method for measuring the labeling efficiency of pseudo‐continuous arterial spin labeling (pCASL) MRI in mice. Methods We propose a method using bidirectional crusher gradients to modulate vascular signals in the azygos pericallosal artery (azPA) of the mouse brain, applied with and without pCASL labeling. The
Xiuli Yang, Yuguo Li, Adnan Bibic, Maria Guadalupe Mora Alvarez, Hanzhang Lu, Zhiliang Wei   +5 more
wiley   +1 more source

Extracardiac Accumulation of Technetium-99m-Pyrophosphate in Transthyretin Cardiac Amyloidosis

, 2021
Koji Takahashi, Daisuke Sasaki, Tomoki Sakaue, Daijiro Enomoto, Shigeki Uemura, Takafumi Okura, Shuntaro Ikeda, Daichi Yamamoto, Taizo Kono, Nobuhisa Yamamura   +9 more
openalex   +1 more source

State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna, Amitava Mitra, Matthew L. Zierhut, Lilly East, Chandra Durairaj   +4 more
wiley   +1 more source