Results 51 to 60 of about 40,633 (287)

Incidence and effect of secondary cardiac amyloidosis on outcomes of patients with t(11;14) multiple myeloma

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe t(11;14)(q13;32) is a common chromosome translocation in multiple myeloma (MM), but its prognostic value remains controversial. Immunoglobulin light chain amyloidosis is commonly secondary to multiple myeloma, which can rapidly cause heart ...
Jinghua Wang, Shuo Yang, Pengjun Liao, Lingji Zeng, Wei Ling, Li Wan, Jianyu Weng, Liye Zhong   +7 more
doaj   +1 more source

Extracardiac 18F-florbetapir imaging in patients with systemic amyloidosis: more than hearts and minds [PDF]

, 2018
PURPOSE: 18F-Florbetapir has been reported to show cardiac uptake in patients with systemic light-chain amyloidosis (AL). This study systematically assessed uptake of 18F-florbetapir in patients with proven systemic amyloidosis at sites outside the heart.
Burniston, M, Hawkins, PN, Manwani, R, McCool, D, Page, J, Ross, JC, Skillen, A, Wagner, T, Wechalekar, AD   +8 more
core   +1 more source

Genome Sequencing Uncovers Additional Findings in Phelan‐McDermid Syndrome

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Phelan‐McDermid syndrome (PMS) is a genetic condition caused by deletions of chromosome 22q13.3 or pathogenic variants in the SHANK3 gene. Neurologic features typically include intellectual disability, autism spectrum disorder, hypotonia, and absent speech, though there is considerable variability even among individuals with the same molecular
Rachel Gore Moses, Morgan Similuk, Alexandra Hehn, Rylee Duncan, Margaret Pekar, Eliza Gordon‐Lipkin, Maria T. Acosta, Deena Zeltser, Nadjalisse Reynolds‐Lallement, Latha Soorya, Mustafa Sahin, Tess Levy, Alexander Kolevzon, Joseph D. Buxbaum, Elizabeth Berry‐Kravis, Craig M. Powell, Jonathan A. Bernstein, Mari Tokita, Bryce A. Seifert, Rajarshi Ghosh, Magdalena A. Walkiewicz, Audrey Thurm   +21 more
wiley   +1 more source

Brain embolic infarction associated with cardiac amyloidosis in a patient with multiple myeloma: a bone marrow-heart-brain crosstalk [PDF]

Precision and Future Medicine, 2018
Cardiac amyloidosis is characterized by the extracellular fibril deposition of amyloid protein in the myocardium. Cerebral embolism caused by cardiac amyloidosis is rare.
Jaeho Kim, Jaehong Park, Sung-Ji Park, Sung Mok Kim, Kihyun Kim, Jong-Won Chung, Oh Young Bang   +6 more
doaj   +1 more source

Expert Perspective: Diagnosis and Treatment of Castleman Disease

Arthritis &Rheumatology, Accepted Article.
Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen, Lu Zhang, David C. Fajgenbaum   +2 more
wiley   +1 more source

Pathological Disulfide Bond Crosslinking: Molecular Insights into Amyloidogenesis and Diseases Progression

ChemBioChem, EarlyView.
This review explores pathological disulfide‐crosslinking as a key driver of amyloidogenic protein misfolding and aggregation. Oxidative and ER stress pathways contributing to disease progression are discussed and emerging therapeutic strategies targeting disulfide‐linked aggregates in neurodegenerative and systemic amyloid diseases are examined ...
Dong Min Kang, Nataliia Lukianenko, Ja‐Hyun Baik, Yun Kyung Kim, Sungsu Lim   +4 more
wiley   +1 more source

Cardiac amyloidosis: a review

Journal of Education, Health and Sport, 2019
Baska Aleksandra, Kazik Jakub, Bojczuk Daria, Racinowski Mariusz, Leis Kamil, Mazur Ewelina, Kałużny Krystian, Gałązka Przemysław. Cardiac amyloidosis: a review. Journal of Education, Health and Sport. 2019;9(3):333-338. eISNN 2391-8306. DOI http://dx.doi.org/zenodo.2597569 http://ojs.ukw.edu.pl/index.php/johs/article/view/6711 https://pbn.nauka.gov ...
Baska, Aleksandra, Kazik, Jakub, Bojczuk, Daria, Racinowski, Mariusz, Leis, Kamil, Mazur, Ewelina, Kałużny, Krystian, Gałązka, Przemysław   +7 more
openaire   +6 more sources

Rationale, application and clinical qualification for NT-proBNP as a surrogate end point in pivotal clinical trials in patients with AL amyloidosis [PDF]

, 2016
Amyloid light-chain (LC) amyloidosis (AL amyloidosis) is a rare and fatal disease for which there are no approved therapies. In patients with AL amyloidosis, LC aggregates progressively accumulate in organs, resulting in organ failure that is ...
Ando, Y, Comenzo, RL, Dispenzieri, A, Gertz, MA, Grogan, M, Lousada, I, Maurer, MS, Merlini, G, Palladini, G, Sanchorawala, V, Wechalekar, A   +10 more
core   +1 more source

Progression and prognostic significance of electrocardiographic findings in patients with cardiac amyloidosis

ESC Heart Failure, Volume 12, Issue 2, Page 809-818, April 2025.
Abstract Aims This study aimed to evaluate the change of the main electrocardiographic (ECG) characteristics and their prognostic role across the main subtypes of cardiac amyloidosis [light‐chain amyloidosis (AL) and hereditary (ATTRv) and wild‐type transthyretin amyloidosis (ATTRwt)].
Alessia Argirò, Mattia Zampieri, Carlotta Mazzoni, Carlo Fumagalli, Michela Baccini, Alessandra Mattei, Alberto Cipriani, Laura De Michieli, Aldostefano Porcari, Gianfranco Sinagra, Marco Merlo, Giacomo Tini, Beatrice Musumeci, Domitilla Russo, Pier Filippo Vianello, Marco Canepa, Roberto Licordari, Gianluca di Bella, Claudio Rapezzi, Federico Perfetto, Francesco Cappelli   +20 more
wiley   +1 more source

Ventricular Arrhythmias in Cardiac Amyloidosis: A Review of Current Literature

Clinical Medicine Insights: Cardiology, 2020
Cardiac Amyloidosis is an infiltrative cardiomyopathy which occurs secondary to deposition of mis-folded protein in the myocardium, with the two most common subtypes being AL amyloidosis and TTR amyloidosis.
Shaun Khanna, Phillip Lo, Kenneth Cho, Rajesh Subbiah   +3 more
doaj   +1 more source