Results 121 to 130 of about 332,173 (306)

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Biosensing Platforms for Cardiac Biomarker Detection

ACS Omega
Myocardial infarction (MI) is a cardiovascular disease that occurs when there is an elevated demand for myocardial oxygen as a result of the rupture or erosion of atherosclerotic plaques. Globally, the mortality rates associated with MI are steadily on the rise.
Zeynep Gerdan, Yeşeren Saylan, Adil Denizli   +2 more
openaire   +4 more sources

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Biomarkers in Cardiac Surgery [PDF]

Blood Purification, 2019
Cem, Çil, Funda Sungur, Biteker, Oğuzhan, Çelik, Bülent, Özlek, Eda, Özlek, Aysel, Gökçek, Volkan, Doğan   +6 more
openaire   +2 more sources

Biomarkers of cardiac disease

Southern African Journal of Anaesthesia and Analgesia, 2011
The American College of Cardiology/American Heart Association (ACC/AHA) has incorporated the Revised Cardiac Risk Index (RCRI) into the algorithm for Perioperative cardiovascular evaluation and care for noncardiac surgery (Fleisher et al, 2007). However, it does not successfully discriminate higher from lower risk patients.
openaire   +1 more source

Cardiac Troponin-I Concentration In Weaned Calves With Bovine Respiratory Disease

Acta Veterinaria, 2015
The aim of this study was to evaluate the serum cardiac troponin I (cTnI) concentrations in weaned calves with moderate and severe bovine respiratory disease.
Hanedan Basak, Kirbas Akin, Dorman Emrullah, Timurkan Mehmet Ozkan, Kandemir Mehmet Fatih, Alkan Omer   +5 more
doaj   +1 more source

Cardiac damage biomarkers and heart rate variability following a 118-km mountain race: relationship with performance and recovery [PDF]

, 2019
This study aimed to assess the release of cardiac damage biomarkers jointly with cardiac autonomic modulation after a mountain ultramarathon. Such knowledge and the possible relationship of these markers with race time is of primary interest to establish
Collado-Boira, Eladio, Hernando, Barbara, MARTINEZ-NAVARRO, IGNACIO, Panizo, Nayara, Sánchez-Gómez, Juan M.   +4 more
core   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

Aptasensor‐based point‐of‐care detection of cardiac troponin biomarkers for diagnosis of acute myocardial infarction

Kaohsiung Journal of Medical Sciences
Acute myocardial infarction (AMI) represents a critical health challenge characterized by a significant reduction in blood flow to the heart, leading to high rates of mortality and morbidity. Cardiac troponins, specifically cardiac troponin I and cardiac
Tharmaraj Vairaperumal, Ping‐Yen Liu
doaj   +1 more source

Application of the American Heart Association/American College of Cardiology/Heart Failure Society of America Heart Failure Staging Guidelines in Adults With Chronic Kidney Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background In 2022 the American Heart Association/American College of Cardiology/Heart Failure Society of America Guidelines for Management of Heart Failure proposed an updated staging system with cardiac biomarkers to diagnose heart failure (HF) and its
Anna M. Zemke, Leila R. Zelnick, Joachim H. Ix, Alan S. Go, Edward D. Siew, Nisha Bansal   +5 more
doaj   +1 more source