Results 131 to 140 of about 332,173 (306)

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Cardiac biomarkers – 2019 [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2019
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Cardiac Troponins As Biomarkers for Cardiac Disease [PDF]

Biomarkers in Medicine, 2019
Passino C., Aimo A., Masotti S., Musetti V., Prontera C., Emdin M., Clerico A.   +6 more
openaire   +3 more sources

Cardiac biomarkers for screening and prognostication of cardiac dysfunction in critically ill patients

ESC Heart Failure
Aims This study aimed to assess the use of high‐sensitivity troponin T (hsTNT) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in screening for cardiac dysfunction [left ventricular (LV) systolic or diastolic dysfunction or right ventricular (RV)
Oscar Cavefors, Freyr Einarsson, Jakob Holmqvist, Odd Bech‐Hanssen, Sven‐Erik Ricksten, Björn Redfors, Jonatan Oras   +6 more
doaj   +1 more source

Predictors of B-line count in hospitalized patients with COVID-19

Frontiers in Cardiovascular Medicine
BackgroundB-lines on lung ultrasound (LUS) are nonspecific signs of increased lung density, which can be secondary to pulmonary congestion, pneumonia, or fibrosis.
Øyvind Johannessen, Øyvind Johannessen, Caroline Espersen, Caroline Espersen, Elke Platz, Elke Platz, Kristoffer Grundtvig Skaarup, Kristoffer Grundtvig Skaarup, Mats Christian Højbjerg Lassen, Mats Christian Højbjerg Lassen, Filip Soeskov Davidovski, Filip Soeskov Davidovski, Jacob Christensen, Jacob Christensen, Jakob Øystein Simonsen, Jakob Øystein Simonsen, Anne Bjerg Nielsen, Anne Bjerg Nielsen, Alia Saed Alhakak, Alia Saed Alhakak, Niklas Dyrby Johansen, Niklas Dyrby Johansen, Morten Sengeløv, Morten Sengeløv, Kasper Iversen, Morten Schou, Peder L. Myhre, Peder L. Myhre, Tor Biering-Sørensen, Tor Biering-Sørensen, Tor Biering-Sørensen, Tor Biering-Sørensen   +31 more
doaj   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Clinical Profile of Patients with Ischaemic Heart Disease and its Correlation with Rheumatoid Factor: A Cross-sectional Study

Journal of Clinical and Diagnostic Research
Introduction: Ischaemic Heart Disease (IHD) remains a leading cause of global mortality, with increasing evidence suggesting the role of inflammatory markers in its pathogenesis.
Sachin Shivnitwar, Sandesh Sadanand Raut, Prasad Bagare, Priya Baluni, Shubhangi Kanitkar, ShreeVidya Yekkaluru   +5 more
doaj   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source