Results 221 to 230 of about 332,173 (306)

Novel cardiac biomarkers and multiple-marker approach in the early detection, prognosis, and risk stratification of cardiac diseases. [PDF]

World J Cardiol
Bokhari SFH, Umais M, Faizan Sattar SM, Mehboob U, Iqbal A, Amir M, Bakht D, Ali K, Hasan AH, Javed MA, Dost W.   +10 more
europepmc   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, EarlyView.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

Cardiac biomarkers for risk stratification in newly diagnosed high-risk multiple myeloma in the GMMG-CONCEPT trial. [PDF]

Cardiooncology
Leypoldt LB, Guo L, Besemer B, Hänel M, Raab MS, Mann C, Michel CS, Reinhardt HC, Blau IW, Görner M, Ko YD, de Wit M, Salwender H, Scheid C, Graeven U, Peceny R, Staib P, Dieing A, Goldschmidt H, Bokemeyer C, Zeller T, Westermann D, Weisel KC, Twerenbold R, Beitzen-Heineke A.   +24 more
europepmc   +1 more source

Tissue‐specific and spatially dependent metabolic signatures perturbed by injury in male and female mice

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis—the leading cause of disability worldwide—disproportionately affects females, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Cardiac biomarkers for detection of coronary artery disease in the community. [PDF]

Sci Rep
Lind L, Alfredsson J, Andersson JSO, Andersson T, Bergström G, Ekblom Ö, Fagman E, Fall T, Hagström E, Isholth HH, Janzon M, Jernberg T, Katsoularis I, Leander K, Leósdóttir M, Magnusson M, Malinovschi A, Rosengren A, GustavSmith J, Spaak J, Svensson P, Söderberg S, Östgren CJ, Engström G.   +23 more
europepmc   +1 more source

TWEAK/Fn14 signaling drives oxidative cardiac injury in systemic lupus erythematosus: Evidence from patient biomarker studies, lupus mouse models, and cardiomyocyte assays

Arthritis &Rheumatology, Accepted Article.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/Fn14 signaling in SLE‐related cardiomyopathy and its potential as a ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

The impact of guided meditations and mindfulness on blood pressure regulation: analyzing the physiological impact of mental health techniques on cardiac biomarkers. [PDF]

Cogent Ment Health
Gururamalingam G, Ramnath T, Ruhela N, Jain R.   +3 more
europepmc   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Systolic and Diastolic Blood Pressure, Cardiac Biomarkers, and Cardiovascular Mortality in Adults Without Cardiovascular Disease. [PDF]

JACC Adv
Guo J, Liu Y, Liu X, Yan M, Zhang Y, Fang S, Wang S, Yu B.   +7 more
europepmc   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source