Results 71 to 80 of about 332,173 (306)

Raman Microscopy at the Organic–Inorganic Interfaces in Human Calcified Aortic Valves Shows the Co‐Existence of Whitlockite Crystals and Carbonated Hydroxyapatite‐Mineralized Collagen Fibrils

Advanced Functional Materials, EarlyView.
This study advances our understanding of aortic valve stenosis by capturing spatially resolved chemical and structural changes at the nanoscale. The findings highlight the potential of combined Raman and electron microscopy for understanding calcification mechanisms across diverse tissue types.
Robin H. M. Van der Meijden, Carolien T. A Kuster, Amber van Broekhoven, Raphaela Allgayer, Luco Rutten, Rona Roverts, Marta Cerruti, Elena Macías‐Sánchez, Jan Hein Cornel, Salloua el Messaoudi, Anat Akiva, Nico Sommerdijk   +11 more
wiley   +1 more source

Rapid, Diagnostic Test for Cardiac Ischemia [PDF]

, 2017
Current methods to detect cardiac ischemia rely on biomarkers such as troponin. Elevated levels of troponin are observed hours after the cardiac event.
Contreras, Julio, Gonzales, Jose, Nasreldeen, Abdelmagid, Physioc, Emerson, Thoresen, Evan   +4 more
core   +2 more sources

The 99th percentile of reference population for cTnI and cTnT assay: Methodology, pathophysiology and clinical implications [PDF]

, 2017
According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit ...
Clerico, Aldo, Masotti, Silvia, Passino, Claudio, Plebani, Mario, Prontera, Concetta, Ripoli, Andrea, Zaninotto, Martina   +6 more
core   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Biomarkers as Diagnostic and Prognostic Tools in Cardiac Disorders: A Comprehensive Review

Journal of Bio-X Research
Cardiac disorders, including myocardial infarction, heart failure, and arrhythmias, are marked causes of morbidity and mortality worldwide. Early diagnosis and effective management of these conditions are crucial for improving patient outcomes ...
Rabinarayan Parhi, Goutam Kumar Jena, Chinam Niranjan Patra, Sruti Jammula   +3 more
doaj   +1 more source

From Clinic to Computation: Multiscale Bioengineering Strategies for Durable Biological Aortic Valve Replacements

Advanced Functional Materials, EarlyView.
Bioprosthetic aortic valves have revolutionized the treatment of aortic stenosis, but their durability is limited by structural valve deterioration (SVD). This review focuses on the pericardial tissue at the heart of these valves, examining how its mechanical properties and calcification drive fatigue and failure.
Gabriele Greco, Pierfrancesco Gaziano, Serena Anglese, Simone Morganti, Carlo de Vincentiis, Ferdinando Auricchio, Michele Marino, Michele Conti   +7 more
wiley   +1 more source

Developing Biomarker Panels to Predict Progression of Acute Kidney Injury After Cardiac Surgery

Kidney International Reports, 2019
Introduction: Acute kidney injury (AKI) is a frequent complication of cardiac surgery, but only a fraction of cardiac surgery patients that experience postoperative AKI have progression to more severe stages. Biomarkers that can distinguish patients that
Kathleen F. Kerr, Eric R. Morenz, Jeremy Roth, Heather Thiessen-Philbrook, Steven G. Coca, Chirag R. Parikh   +5 more
doaj   +1 more source

Cardiac biomarkers and ultrasonography as tools in prediction and diagnosis of traumatic pericarditis in Egyptian buffaloes [PDF]

Veterinary World, 2016
Aim: This study was designed to evaluate the cardiac biomarkers and ultrasonography in prediction and early diagnosis of traumatic pericarditis (TP) in Egyptian buffaloes.
Noura E. Attia
doaj   +1 more source

ST2 and Multimarker Testing in Acute Decompensated Heart Failure [PDF]

, 2015
Most data on heart failure biomarkers have been derived from patient cohorts with chronic disease. However, risk prediction in patients admitted with acute decompensated heart failure (ADHF) remains a challenge.
Antoni, Md, Bayes, Genis, DI SOMMA, Salvatore, Maisel, Alan S., Md,, Md,, Md,, Mebazaa, Alexandre   +7 more
core   +1 more source

Multi‐Scale Interface Engineering of MXenes for Multifunctional Sensory Systems

Advanced Functional Materials, EarlyView.
MXenes, as two‐dimensional transition metal carbides and nitrides, demonstrate remarkable capabilities for multifunctional sensing applications. This review systematically examines multi‐scale interface engineering approaches that enhance sensing performance, enable diverse detection functionalities, and improve system‐level compatibility in MXene ...
Jiaying Liao, Sin‐Yi Pang, Jianhua Hao
wiley   +1 more source