Results 151 to 160 of about 335,049 (297)

Cardiac Glycosides Induce Resistance to Tubulin-Dependent Anticancer Drugs in Androgen-Independent Human Prostate Cancer

, 2009
Due to high prevalence and mortality and the lack of effective therapies, prostate cancer is one of the most crucial health problems in men. Drug resistance aggravates the situation, not only in human prostate cancer but also in other cancers.
CHUEH, SHIH-CHIEH;TENG, CHE-MING, 闕士傑;鄧哲明   +1 more
core  

Optimization of Magnetic Milli‐Spinner for Robotic Endovascular Intervention

Advanced Robotics Research, EarlyView.
This work presents the design optimization of a multifunctional magnetic milli‐spinner for high‐speed propulsion and efficient clot debulking. The optimized design achieves an ultrafast swimming velocity of 55 cm/s (≈175 body lengths/s) in saline water, enabling stable upstream swimming against strong physiological flows and establishing magnetic milli‐
Lu Lu, Luca Higgins, Jack Bernardo, Ruike Renee Zhao   +3 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Impact of cardiac cycle and respiratory rhythm phase on visual attention in healthy young and older adults. [PDF]

Sci Rep
Santhana Gopalan PR, Hämäläinen J, Penttonen M, Nokia MS.   +3 more
europepmc   +1 more source

Morphological Changes of Anomalous Coronary Arteries From the Aorta During the Cardiac Cycle Assessed by IVUS in Resting Conditions. [PDF]

Circ Cardiovasc Interv, 2023
Formato GM, Agnifili ML, Arzuffi L, Rosato A, Ceserani V, Zuniga Olaya KG, Secchi F, Deamici M, Conti M, Auricchio F, Bedogni F, Frigiola A, Lo Rito M.   +12 more
europepmc   +1 more source

Conscious somatosensory perception varies across the cardiac cycle

Interoceptive signals can modulate the access of external stimuli to perceptual consciousness. For example, visually masked fearful faces are more likely to be detected when presented during cardiac systole compared to diastole (Garfinkel et al., 2014 ...
Motyka, P., Grund, M., Forschack, N., Villringer, A. ; https://orcid.org/, Gaebler, M.   +4 more
core  

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Somatosensory perception varies across the cardiac cycle

Internal bodily states influence perceptual, affective and cognitive processes. Our group has recently provided evidence that the detection of somatosensory near-threshold stimuli increases during the late phase of the cardiac cycle (diastole).
Motyka, P., Grund, M., Nikulin, V. ; https://orcid.org/, Fivos, I., Nierhaus, T., Forschack, N., Villringer, A. ; https://orcid.org/, Gaebler, M., Esra, A.   +8 more
core  

Cardiac dynamics during upright cycle exercise in boys.

, 2000
Insight into the cardiac responses to exercise necessitates an understanding of both physiological data and cardiac dimensional changes. This study was designed to assess cardiovascular alterations during progressive upright cycle exercise in ten ...
Rowland, Thomas, MD
core  

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source