Results 41 to 50 of about 4,359,782 (346)

Resting-State Neural Firing Rate Is Linked to Cardiac-Cycle Duration in the Human Cingulate and Parahippocampal Cortices

Journal of Neuroscience, 2019
Stimulation and functional imaging studies have revealed the existence of a large network of cortical regions involved in the regulation of heart rate. However, very little is known about the link between cortical neural firing and cardiac-cycle duration
Kayeon Kim, J. Ladenbauer, M. Babo-Rebelo, A. Buot, K. Lehongre, C. Adam, D. Hasboun, V. Lambrecq, V. Navarro, S. Ostojic, C. Tallon-Baudry   +10 more
semanticscholar   +1 more source

Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro. [PDF]

PLoS ONE, 2009
BACKGROUND:Mammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Carmen H Coxon, Katrina A Bicknell, Fleur L Moseley, Gavin Brooks   +3 more
doaj   +1 more source

Cardiac alternans and intracellular calcium cycling [PDF]

Clinical and Experimental Pharmacology and Physiology, 2014
SummaryCardiac alternans refers to a condition in which there is a periodic beat‐to‐beat oscillation in electrical activity and the strength of cardiac muscle contraction at a constant heart rate. Clinically, cardiac alternans occurs in settings that are typical for cardiac arrhythmias and has been causally linked to these conditions.
Joshua N. Edwards, Lothar A. Blatter
openaire   +3 more sources

Early Postnatal Cardiac Stress Does Not Influence Ventricular Cardiomyocyte Cell-Cycle Withdrawal

Journal of Cardiovascular Development and Disease, 2021
Congenital heart disease (CHD) is the most common birth defect. After birth, patients with CHD may suffer from cardiac stress resulting from abnormal loading conditions.
Marie Günthel, Karel van Duijvenboden, Jorn Jeremiasse, Maurice J. B. van den Hoff, Vincent M. Christoffels   +4 more
doaj   +1 more source

Learning by heart: cardiac cycle reveals an effective time window for learning.

Journal of Neurophysiology, 2018
Cardiac cycle phase is known to modulate processing of simple sensory information. This effect of the heartbeat on brain function is likely exerted via baroreceptors, the neurons sensitive for changes in blood pressure.
Tomi Waselius, J. Wikgren, Hanna Halkola, M. Penttonen, M. Nokia   +4 more
semanticscholar   +1 more source

The influence of physical exercise on the relation between the phase of cardiac cycle and shooting accuracy in biathlon

European Journal of Sport Science, 2018
This study examined the influence of physical exercise on the relation between shooting accuracy and the phase of the cardiac cycle in which the shot is fired.
G. Gallicchio, T. Finkenzeller, Gerold Sattlecker, S. Lindinger, K. Hoedlmoser   +4 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Cardiac cycle gated cognitive-emotional control in superior frontal cortices

NeuroImage, 2020
Accumulating evidence suggests that peripheral physiological processes, such as the cardiac cycle, impact the individual's ability to appropriately exert control over behavior and emotional responses.
Nico Adelhöfer, Marie Luise Schreiter, Christian Beste   +2 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source