Results 81 to 90 of about 568,260 (340)

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy.

PLoS ONE, 2014
Cardiac hypertrophy appears to be a specialized form of cellular growth that involves the proliferation control and cell cycle regulation. NIMA (never in mitosis, gene A)-related kinase-6 (Nek6) is a cell cycle regulatory gene that could induce centriole
Zhouyan Bian, Haihan Liao, Yan Zhang, Qingqing Wu, Heng Zhou, Zheng Yang, Jinrong Fu, Teng Wang, Ling Yan, Difei Shen, Hongliang Li, Qizhu Tang   +11 more
doaj   +1 more source

Calcium Imparts Advanced Functionalities to Silk Hydrogels for Biofabrication and Biomedical Innovation

Advanced Functional Materials, EarlyView.
The addition of calcium ions to silk fibroin enhances the hydrogel properties and, when combined with visible light crosslinking, enables compatibility with advanced light‐based fabrication techniques. Calcium ions extend the shelf‐life of silk and facilitate the fabrication of multizonal, multilayered constructs for advanced stimuli‐responsive ...
Hien A. Tran, Anton Maraldo, Chi Cong Nguyen, Trinh Thi‐Phuong Ho, Lauryn Srethbhakdi, Habib Joukhdar, Quinn van Hilst, Syamak Farajikhah, Fariba Dehghani, Thanh Nho Do, Khoon S. Lim, Jelena Rnjak‐Kovacina   +11 more
wiley   +1 more source

Three-dimensional structure of the flow inside the left ventricle of the human heart

, 2013
The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data obtained in ...
Cenedese, A., Espa, S., Fortini, S., Querzoli, G.   +3 more
core   +1 more source

Reduction of radiation dose for coronary computed tomography angiography using prospective electrocardiography-triggered high-pitch acquisition in clinical routine [PDF]

, 2018
Purpose: To evaluate the image quality, radiation exposure, and means of application in a group of patients who underwent coronary computed tomography angiography (CCTA) performed with low-dose prospective electrocardiography (ECG)-triggered acquisition ...
Chaosuwannakit, Narumol, Makarawate, Pattarapong   +1 more
core   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Tricuspid annulus: A spatial and temporal analysis

Annals of Cardiac Anaesthesia, 2016
Background: Traditional two-dimensional (2D) echocardiographic evaluation of tricuspid annulus (TA) dilation is based on single-frame measurements of the septolateral (S-L) dimension.
Ziyad O Knio, Mario Montealegre-Gallegos, Lu Yeh, Bilal Chaudary, Jelliffe Jeganathan, Robina Matyal, Kamal R Khabbaz, David C Liu, Venkatachalam Senthilnathan, Feroze Mahmood   +9 more
doaj   +1 more source

UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia

JCI Insight, 2022
Developmental cardiac tissue is regenerative while operating under low oxygen. After birth, ambient oxygen is associated with cardiomyocyte cell cycle exit and regeneration. Likewise, cardiac metabolism undergoes a shift with cardiac maturation.
Vagner O.C. Rigaud, Clare Zarka, Justin Kurian, Daria Harlamova, Andrea Elia, Nicole Kasatkin, Jaslyn Johnson, Michael Behanan, Lindsay Kraus, Hannah Pepper, Nathaniel W. Snyder, Sadia Mohsin, Steven R. Houser, Mohsin Khan   +13 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]

, 2009
Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates, A. F Hurlstone, A. F Moorman, A. G Passerini, A. M Malek, A. R Brooks, A. S Forouhar, Arian S. Forouhar, B. C Groenendijk, B. C Groenendijk, C Ethier, C Hahn, C. H Kim, D Beis, D. J Milan, David Wu, Diane Plummer, E Berdougo, E. C Walsh, E. J Armstrong, G Bendig, G Garcia-Cardena, G. B Atkins, G. P Sorescu, H Kokubo, H. J Auman, Hiroshi Hamada, J Alexander, J Pan, J. L Galloway, J. N Chen, J. R Hove, J. S Lee, Julien Vermot, K. M Parmar, L. A Timmerman, M Liebling, M Xin, M Yamada, Michael Liebling, Morteza Gharib, N Sultana, N. C Chi, N. C Chi, P. J Scherz, R. D Kortschak, R. J Dekker, R. J Dekker, S Isogai, S Quintin, S. M McCormick, S. M Meadows, S. W Jin, Scott E. Fraser, T Bartman, T Bartman, T Lecuit, T Lecuit, T. R Cummins, X. L Wang, Y Fung   +60 more
core   +5 more sources