Results 111 to 120 of about 576,149 (314)

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress

, 2008
An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Lin Leng, Richard Bucala, Erin Lane, Heng Ma, Jingying Wang, Jun Ren, Wenkui Wang, Ji Li   +7 more
core  

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. [PDF]

, 2006
04.11.13 KB. Ok to add published version to spiral, oa article.BACKGROUND: Organ transplantation is presently often the only available option to repair a damaged heart.
Peters, NS, MacLeod Kenneth T, Patel Pravina, Themis Michael, Coutelle, Charles, Ma, Yu-Ling, Tolmachov Oleg, Tolmachov, Oleg, Yu-Ling Ma, Coutelle Charles, Yvonne Kienast, MacLeod, K, Tolmachov, O, Peters, N, Hilmar Spohr, Peters Nicholas S, Ma, Y, Patel, Pravina, Spohr, Hilmar, Kienast Yvonne, Themis, Michael, Ullrich, N, Ullrich Nina D, Pravina Patel, Ma Yu-Ling, Charles Coutelle, Kienast, Y, MacLeod, Kenneth T, Peters, Nicholas S, Ullrich, ND, Coutelle, C, Spohr Hilmar, Ma, YL, Spohr, H, Oleg Tolmachov, Nina D Ullrich, Macleod, KT, Themis, M, Kenneth T MacLeod, Nicholas S Peters, Michael Themis, Kienast, Yvonne, Ullrich, Nina, Patel, P   +43 more
core   +1 more source

Nuclear Receptor Subfamily 4 Group A Member 1 Exacerbates Cardiac Remodeling by Inhibiting Mitochondrial Function Through the Peroxisome Proliferator‐Activated Receptor γ Coactivator‐1α/Nuclear Respiratory Factor 1/Transcription Factor A Mitochondrial Axis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Heart failure is characterized by cardiac dysfunction, cardiac remodeling, and mitochondrial dysfunction. NR4a1 (nuclear receptor subfamily 4 group A member 1) plays a crucial role in regulating mitochondrial function and biological ...
Chun‐yan Kong, Ming‐yu Wang, Yu‐lan Ma, Zhen Guo, Zheng Yang, Qi‐zhu Tang   +5 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Matrix Metalloproteinase Inhibition Improves Cardiac Dysfunction and Remodeling in 2-Kidney, 1-Clip Hypertension

, 2010
Background: Enhanced cardiac matrix metalloproteinase activity (MMPs) has been associated with ventricular remodeling and cardiac dysfunction. It is unknown whether MMPs contribute to systolic/diastolic dysfunction and compensatory remodeling in 2-kidney,
TANUS-SANTOS, Jose E., SILVA, Carlos A., ROSSI, Marcos A., GERLACH, Raquel Fernanda, CASTRO, Michele M., FAZAN JR., Rubens, PRADO, Cibele M., RIZZI, Elen   +7 more
core   +1 more source

The ubiquitin–proteasome system in cardiac dysfunction

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2008
Abstract Since proteins play crucial roles in all biological processes, the finely tuned equilibrium between their synthesis and degradation regulates cellular homeostasis. Controlling the quality of proteome informational content is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded,
Mearini, Giulia, Schlossarek, Saskia, Willis, Monte S., Carrier, Lucie   +3 more
openaire   +3 more sources

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Função e reatividade cardíaca in situ na sepse em ratos: diferenças entre gêneros e modelos experimentais [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.A sepse representa a principal causa de mortes em unidades de terapia intensiva. A disfunção cardíaca
Gonçalves, Ronald Paiva Moreno
core  

Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction [PDF]

, 2018
Long-chain fatty acids are the main cardiac substrates from which ATP is generated continually to serve the high energy demand and sustain the normal function of the heart. Under healthy conditions, fatty acid beta-oxidation produces 50-70% of the energy
Glatz, Jan F. C., Luiken, Joost J. F. P., Neumann, Dietbert, Liu, Yilin, Neumann, Dietbert; id_orcid   +4 more
core   +1 more source