Results 121 to 130 of about 1,793,619 (305)

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Cardiac function and dysfunction in hypertension

Cleveland Clinic Journal of Medicine, 1994
Hypertension is the most common condition of increased left ventricular afterload that affects the cardiovascular system.To review the effects of increased blood pressure on cardiac function.In early or borderline hypertension, cardiac output increases but intravascular volume remains normal.
openaire   +2 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1

Cardiovascular Diabetology
Dynamin-related protein 1 (Drp1) is a crucial regulator of mitochondrial dynamics, the overactivation of which can lead to cardiovascular disease. Multiple distinct posttranscriptional modifications of Drp1 have been reported, among which S-nitrosylation
Yuqiong Chen, Su Li, Bo Guan, Xiaopei Yan, Chao Huang, Yingqiang Du, Fan Yang, Nannan Zhang, Yafei Li, Jian Lu, Jiankang Wang, Jun Zhang, Zhangwei Chen, Chao Chen, Xiangqing Kong   +14 more
doaj   +1 more source

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12

Scientific Reports, 2018
Aldosterone (Aldo) contributes to mitochondrial dysfunction and cardiac oxidative stress. Using a proteomic approach, A-kinase anchor protein (AKAP)-12 has been identified as a down-regulated protein by Aldo in human cardiac fibroblasts.
Jaime Ibarrola, Rafael Sadaba, Ernesto Martinez-Martinez, Amaia Garcia-Peña, Vanessa Arrieta, Virginia Alvarez, Amaya Fernández-Celis, Alicia Gainza, Victoria Cachofeiro, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Frederic Jaisser, Natalia Lopez-Andres   +12 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Exercise cardiac MRI unmasks cardiac dysfunction in childhood and adolescent cancer survivors with reduced cardiopulmonary fitness

, 2020
Exercise cardiac MRI unmasks cardiac dysfunction in childhood and adolescent cancer survivors with reduced cardiopulmonary ...
C Toro (13463889), Steve Fraser (13093977), B Costello (13463886), K Janssens (13357116), R Conyers (13463892), EJ Howden (14447325), Robin Daly (13091373), S Foulkes (13312119), A La Gerche (13357122), H Dillon (13739455), DA Elliott (9127397)   +10 more
core  

Factors associated With Long-Term Cardiac Dysfunction in Neonatal Lupus

, 2019
OBJECTIVES: Cardiac manifestations of neonatal lupus (NL) have been associated with significant morbidity and mortality; however, there is minimal information on long-term outcomes of affected individuals.
Buyon, Jill P., Peter M Izmirly, Buyon, Jill P, Friedman, Deborah M., Mimi Y Kim, Izmirly, Peter M., Kim, Mimi Y, Bomar, Rebecca P., Eisenberg, Ruth, Deborah M Friedman, Golpanian, Rachel S., Golpanian, Rachel Shireen, Ruth Eisenberg, Saxena, Anit, Kim, Mimi Y., Jill P Buyon, Rebecca P Bomar, Izmirly, Peter M, Saxena, Amit, Bomar, Rebecca P, Amit Saxena, Rachel Shireen Golpanian   +21 more
core   +1 more source

Correlation of Cardiac Autonomic Dysfunction with CD4 Count in Human Immunodeficiency Virus Patients [PDF]

Journal of Krishna Institute of Medical Sciences University, 2019
Background: Almost all organs and systems in the body are affected by Human Immunodeficiency Virus (HIV) infection. Autonomic nervous system involvement and cardiac autonomic dysfunction is known to affect severely the quality of life in HIV patients due
Sharan Badiger
doaj  

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source