Results 131 to 140 of about 576,149 (314)

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12

Scientific Reports, 2018
Aldosterone (Aldo) contributes to mitochondrial dysfunction and cardiac oxidative stress. Using a proteomic approach, A-kinase anchor protein (AKAP)-12 has been identified as a down-regulated protein by Aldo in human cardiac fibroblasts.
Jaime Ibarrola, Rafael Sadaba, Ernesto Martinez-Martinez, Amaia Garcia-Peña, Vanessa Arrieta, Virginia Alvarez, Amaya Fernández-Celis, Alicia Gainza, Victoria Cachofeiro, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Frederic Jaisser, Natalia Lopez-Andres   +12 more
doaj   +1 more source

Cardiac function and dysfunction in hypertension

Cleveland Clinic Journal of Medicine, 1994
Hypertension is the most common condition of increased left ventricular afterload that affects the cardiovascular system.To review the effects of increased blood pressure on cardiac function.In early or borderline hypertension, cardiac output increases but intravascular volume remains normal.
openaire   +2 more sources

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Correlation of Cardiac Autonomic Dysfunction with CD4 Count in Human Immunodeficiency Virus Patients [PDF]

Journal of Krishna Institute of Medical Sciences University, 2019
Background: Almost all organs and systems in the body are affected by Human Immunodeficiency Virus (HIV) infection. Autonomic nervous system involvement and cardiac autonomic dysfunction is known to affect severely the quality of life in HIV patients due
Sharan Badiger
doaj  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data

, 2012
Background: Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).
Günter AJ Riegger, Sabine Fredersdorf, Vetter, Roland, Eschenhagen, Thomas, Weil, Joachim, Joachim Weil, Thumann, Christian, Wolfram H Zimmermann, Heribert Schunkert, Riegger, Günter A. J., Luchner, Andreas, Luchner Andreas, Vetter Roland, Zimmermann, Wolfram-Hubertus, Graf, Tobias, Schunkert, Heribert, Thumann Christian, Andreas Luchner, Weil Joachim, Fredersdorf Sabine, Roland Vetter, Schunkert Heribert, Eschenhagen Thomas, Tobias Graf, Graf Tobias, Zimmermann, Wolfram H., Thomas Eschenhagen, Zimmermann Wolfram H, Christian Thumann, Riegger, Guenter A. J., Fredersdorf, Sabine, Riegger Günter AJ   +31 more
core   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

An analysis of defibrillation and cardiac resynchronization therapy strategies in patients with failing systemic right ventricles

, 2007
Includes bibliographical references (leaves 52-56).The expanding application of cardiac resynchronization (CRT) and implantable cardioverter-defibrillator therapy (lCD) to include patients with congenital heart disease requires careful evaluation of ...
Michael, Kevin A
core  

NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis.

, 2012
The innate immune system is responsible for the initial response of an organism to potentially harmful stressors, pathogens or tissue injury, and accordingly plays an essential role in the pathogenesis of many inflammatory processes, including some ...
Carmen Delgado, Begoña Lavin (136479), Bosca Gomar, Lisardo, Begoña Lavin, Delgado, Carmen, Lisardo Boscá, Flores Landeira, Juana María, Fernández-Velasco, María, Zaragoza, Carlos, Patricia Prieto, Verónica Terrón (136468), Mónica Gómez-Parrizas, Carmen Delgado (136473), María Fernández-Velasco (105894), Prieto, Patricia, Gómez-Parrizas, Mónica, Carlos Zaragoza, Paloma Martín-Sanz (114631), Gemma Benito (136469), Juana M Flores, Eduardo López-Collazo, Patricia Prieto (136466), López-Collazo, Eduardo, Mónica Gómez-Parrizas (136482), Eduardo López-Collazo (136485), Lisardo Boscá (114622), María Fernández-Velasco, Gemma Benito, Carlos Zaragoza (136476), Juana M. Flores (136471), Martín Sanz, Paloma, Terrón, Verónica, Benito, Gemma, Lavín Plaza, Begoña, Verónica Terrón, Paloma Martín-Sanz   +35 more
core   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source