Results 151 to 160 of about 576,149 (314)

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Assessing Left Ventricular Dysfunction in Pediatric Chronic Kidney Disease Patients: A 2D Echocardiography Study From Ethiopia

International Journal of Nephrology
Conclusion: Most of the children with CKD had evidence of cardiac remodeling. Diastolic dysfunction was the most common type of functional cardiac impairment, as opposed to systolic dysfunction.
Elham Sany Shemsu, Bezaye Abebe Bekele, Etsegenet Gedlu Behailu, Yabets Tesfaye Kebede, Bekri Delil Mohammed   +4 more
doaj   +1 more source

From Arterial to Cardiac Dysfunction [PDF]

Angiology, 2020
Zanoli L., Gaudio A., Castellino P.
openaire   +3 more sources

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

An investigation into the mechanisms, consequences and moderators of intradialytic hypotension in paediatric haemodialysis [PDF]

, 2009
The relationship between hypertension and cardiovascular morbidity has long been recognised. However evidence is mounting implicating hypotension and not hypertension as the predominant risk factor for mortality.
Hothi, D K, Hothi, D.K.
core  

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Novel model of cardiac hypertrophy with cardiorenal dysfunction

Scientific Reports
Cardiovascular diseases (CVDs) are a leading global cause of mortality. Hypertension (HTN) is a primary risk factor for developing and progressing CVDs, like cardiac hypertrophy and renal dysfunction.
Amanda de Almeida Silva, Leonardo Jensen, Juliana Romeu Marques, Bruno Nascimento-Carvalho, Leandro Eziquiel de Souza, Maikon Barbosa da Silva, Nathalia Juocys Dias Moreira, Mariana Matera Veras, Dunia Waked, Felipe Lima Souza, Mirela Aparecida Rodrigues Santinho, Guilherme Lunardon, Elia Garcia Caldini, Lúcia da Conceição Andrade, Gabriela Placoná Diniz, Maria Cláudia Irigoyen   +15 more
doaj   +1 more source

Defining Cardiac Dysfunction in ADPKD

Kidney360, 2023
openaire   +2 more sources

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source