Results 161 to 170 of about 511,264 (218)

Development of Cancer Therapy-Related Cardiac Dysfunction Is Associated With Disease Progression in Breast Cancer. [PDF]

Circ Rep
Haga F, Oikawa M, Tani T, Yokokawa T, Misaka T, Kaneshiro T, Yoshihisa A, Tachibana K, Otake T, Ishida T, Takeishi Y.   +10 more
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Lifetime Deletion of Skeletal Muscle Keap1 Attenuates Aging-Induced Cardiac Dysfunction via an Nrf2-Antioxidant Mechanism. [PDF]

Antioxidants (Basel)
Sharma K, Pribil Pardun S, Dhyani N, Zucker IH, Nair BG, Nair SS, Kumar V, Gao L.   +7 more
europepmc   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Subclinical cardiac dysfunction and circulating markers of brain injury in older adults: The cardiovascular health study. [PDF]

J Stroke Cerebrovasc Dis
Abe TA, Tressel W, Bartz TM, Gottdiener JS, Kamel H, Kizer JR, Longstreth WT, Shah SJ, Djoussée L, Mukamal KJ.   +9 more
europepmc   +1 more source

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

Advanced Science, EarlyView.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang, Xin Hua, Ziwei Fan, Jiaxin Zhao, Yuan Zhang, Qiaoyi Zhang, Xi Qu, Shengli Pan, Bingbing Wan, Shiyin Yang, Jia Li, Xu Zhang   +11 more
wiley   +1 more source

Irisin deficiency exacerbates cardiac dysfunction and enhances hemorrhage injury in hemorrhage/resuscitation. [PDF]

Am J Physiol Regul Integr Comp Physiol
Kulthinee S, Wang L, Slate-Romano J, Huang L, Zhao T, Dubielecka PM, He JQ, Zhuang S, Zhao TC.   +8 more
europepmc   +1 more source

Enhancement of Calcium Ion Permeation via Resonant Coupling of Ion and Terahertz Waves in Voltage Gated Calcium Channels

Advanced Science, EarlyView.
We introduce a novel, ion‐targeted strategy to enhance calcium permeation in voltage gated calcium channels. By directly driving the ions’ coherent collective motion via resonant coupling with a 1.65 THz field, we lower the inter‐site energy barrier, inducing a statistically significant enhancement of ion influx.
Zihao Zhang, Yuankun Sun, Xinqiao Zhou, Sunchao Huang, Shengpeng Yang, Shaomeng Wang, Yubin Gong   +6 more
wiley   +1 more source

Early diagnostic value of novel biomarkers for breast cancer therapy-related cardiac dysfunction. [PDF]

ESC Heart Fail
Wang Z, Wu Y, He J, Gao D, Zuo Z.
europepmc   +1 more source