Results 241 to 250 of about 1,793,619 (305)

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Association between comorbidity burden and subclinical cardiac dysfunction in cancer patients prior to chemotherapy. [PDF]

Hong Kong Physiother J
Kartikasari DP, Pikir BS, Lefi A, Widiandani T, Suprabawati DGA, Putri AE, Ardhiansyah AO, Agustina ED.   +7 more
europepmc   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Subclinical cardiac dysfunction in transfusion-dependent beta-thalassemia children, an experience from central India: A comparative cross-sectional study. [PDF]

Ann Pediatr Cardiol
Meshram RM, Chopde S, Rashid A.
europepmc   +1 more source

An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling

Advanced Science, EarlyView.
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen, Alexander Chen, Quincy Lyons, Van K. Ninh, Maxwell C. McCabe, Colin Luo, Benjamin D. Bridgelal, Connor Uhre, Julian Cheng, Kate E. Reimold, Selena Cao, Kirk C. Hansen, Kevin R. King, Karen L. Christman   +13 more
wiley   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Molecular insights in HIV-associated cardiac dysfunction. [PDF]

Commun Med (Lond)
Valero-Muñoz M, Saw EL, Pimentel DR, Gower AC, Srinivasa S, Zanni MV, Toribio M, Grinspoon SK, Sam F.   +8 more
europepmc   +1 more source

Rel⁺ macrophages disturbing cardiac niche contributes to cardiac dysfunction following sepsis. [PDF]

J Transl Med
Zhou Y, Zhu Y, Wu Y, Yang S, Xiang X, Ouyang X, Li Q, Wang X, Wang L, Liu L, Li T.   +10 more
europepmc   +1 more source

Role of β-adrenergic signaling in the development of Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice. [PDF]

Sci Rep
Matsuo I, Suita K, Ohnuki Y, Ishikawa M, Ito A, Abe M, Mitsubayashi T, Mototani Y, Matsubara R, Nariyama M, Nomura T, Hayakawa Y, Chikazu D, Matsuo A, Okumura S.   +14 more
europepmc   +1 more source

Real-world incidence of cancer therapy-related cardiac dysfunction in a large, diverse, and contemporary cohort. [PDF]

ESC Heart Fail
Thadani SR, Go AS, Liu JY, Parikh RV, Garcia EA, Cespedes Feliciano EM, Bhatt AS, Adatya S, Kwan ML, Lin AY, Liu R, Lopez A, Nugent JR, Ouyang D, Yen AH, Zaroff JG, Ambrosy AP.   +16 more
europepmc   +1 more source