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Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity
Journal of Medicinal Chemistry, 1986Digitoxigenin alpha-L-, beta-L-, alpha-D-, and beta-D-glucosides; alpha-L-, beta-L-, alpha-D-, and beta-D-mannosides; and alpha-L- and beta-L-rhamnosides were stereoselectively synthesized from the corresponding sugar tetrabenzyl trichloroacetimidates.
H, Rathore +3 more
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1994
Publisher Summary This chapter discusses endogenous cardiac glycosides. The cardiac glycosides comprise a class of organic compounds derived largely from plant sources that have been used for millennia as therapeutic agents. Other clinically relevant cardiac glycosides are derived from the leaves of Digitalis lanata from which digitoxin and digoxin
R A, Kelly, T W, Smith
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Publisher Summary This chapter discusses endogenous cardiac glycosides. The cardiac glycosides comprise a class of organic compounds derived largely from plant sources that have been used for millennia as therapeutic agents. Other clinically relevant cardiac glycosides are derived from the leaves of Digitalis lanata from which digitoxin and digoxin
R A, Kelly, T W, Smith
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Naturally occurring cardiac glycosides
Medical Journal of Australia, 1986Cardiac glycoside poisoning from the ingestion of plants, particularly of oleanders, occurs with reasonable frequency in tropical and subtropical areas. We have assessed a variety of plant specimens for their cardiac glycoside content by means of radioimmunoassays with antibodies that differ in their specificity for cardiac glycosides.
Radford, DJ +3 more
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Chromatography of cardiac glycosides
Journal of Chromatography B: Biomedical Sciences and Applications, 1990Most of the recently reported methods for the quantitation of cardiac glycosides have been for digoxin and its metabolites. Recent procedures using high-performance liquid chromatography-radioimmunoassay (HPLC-RIA) and HPLC following derivatization show appreciable improvements in accuracy and specificity for quantitating digoxin in the low nanogram ...
S J, Vetticaden, A, Chandrasekaran
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C14-Labeled Cardiac Glycosides
1966An essential structural and pharmacological characteristic of cardenolides is an a, s-unsaturated γ-lactone ring (the butenolide ring) in the 17 β-position. Ruzicka, Reichstein, and Furst [1] and others [2–5] first demonstrated the possibility of its synthesis from steroids other than cardenolides by means of the Reformatsky reaction [6,7]. By reaction
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