Results 1 to 10 of about 177,041 (162)
MicroRNAs in Cardiac Hypertrophy [PDF]
International Journal of Molecular Sciences, 2019 Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be beneficial for a short period of time, to maintain a normal cardiac output in times of need; however, chronic cardiac hypertrophy may ...
Gianfranco Pintus +2 more
exaly +7 more sources
CAMTA in Cardiac Hypertrophy [PDF]
Cell, 2006 In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction ...
Schwartz, Robert J. +1 more
openaire +3 more sources
Cardiac hypertrophy at autopsy [PDF]
Virchows Archiv, 2021 AbstractSince cardiac hypertrophy may be considered a cause of death at autopsy, its assessment requires a uniform approach. Common terminology and methodology to measure the heart weight, size, and thickness as well as a systematic use of cut off values for normality by age, gender, and body weight and height are needed.
Basso C. +9 more
openaire +8 more sources
Cardiac Nonmyocytes in the Hub of Cardiac Hypertrophy [PDF]
Circulation Research, 2015 Cardiac hypertrophy is characterized by complex multicellular alterations, such as cardiomyocyte growth, angiogenesis, fibrosis, and inflammation. The heart consists of myocytes and nonmyocytes, such as fibroblasts, vascular cells, and blood cells, and these cells communicate with each other directly or indirectly via a variety of autocrine or ...
Takehiro, Kamo +2 more
openaire +2 more sources
Adiponectin and Cardiac Hypertrophy in Acromegaly [PDF]
Advances in Clinical and Experimental Medicine, 2016 Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied.The aim of this study was to find out how adiponectin levels
Sabriye, Gurbulak +7 more
openaire +6 more sources
Enigma in cardiac hypertrophy [PDF]
Cardiovascular Research, 2010 The Enigma subfamily belongs to the PDZ- (for PSD-95, DLG, ZO-1) and LIM- (for LIN-11, Isl-1, MEC-3) encoding protein family. This family is composed of at least four different members: Enigma (also called PD-LIM7; LMP-1), Enigma homologue (ENH), ZASP/Cypher/Oracle, and LMP-4.
openaire +2 more sources
Glucose metabolism and cardiac hypertrophy [PDF]
Cardiovascular Research, 2011 The most notable change in the metabolic profile of hypertrophied hearts is an increased reliance on glucose with an overall reduced oxidative metabolism, i.e. a reappearance of the foetal metabolic pattern. In animal models, this change is attributed to the down-regulation of the transcriptional cascades promoting gene expression for fatty acid ...
Stephen C, Kolwicz, Rong, Tian
openaire +2 more sources
Molecular biomarkers in cardiac hypertrophy [PDF]
Journal of Cellular and Molecular Medicine, 2019 AbstractCardiac hypertrophy is characterized by an increase in myocyte size in the absence of cell division. This condition is thought to be an adaptive response to cardiac wall stress resulting from the enhanced cardiac afterload. The pathogenesis of heart dysfunction, which is one of the primary causes of morbidity and mortality in elderly people, is
Liu Zhu +4 more
openaire +2 more sources
Genetic determinants of cardiac hypertrophy [PDF]
Current Opinion in Cardiology, 2008 Cardiac hypertrophy is a common phenotypic response of the heart to stimulants. It is associated with increased morbidity and mortality in various cardiovascular disorders. Genetic factors are important determinants of phenotypic expression of cardiac hypertrophy, whether in single-gene disorders or in complex traits. We focus on the molecular genetics
openaire +2 more sources
Fueling Cardiac Hypertrophy [PDF]
Circulation Research, 2020 Timothy R, Matsuura +2 more
openaire +2 more sources