Results 161 to 170 of about 280,420 (306)

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Chronic intermittent hypoxia exacerbates isoproterenol-induced cardiac hypertrophy and apoptosis. [PDF]

Front Cardiovasc Med
Zhang Y, Zhang M, Jiang H, Fang F.
europepmc   +1 more source

Understanding longitudinal bi-ventricular structural and functional changes in a Pulmonary Hypertension Sugen-Hypoxia rat model by Cardiac Magnetic Resonance Imaging [PDF]

, 2020
Buist, Hanna, Church, A. Colin, Gallagher, Lindsay, Holmes, William M., Hughes, Colin, Jayasekera, Geeshath, Johnson, Martin K., MacLean, Mandy R., Mullin, James, Nilsen, Margaret, Peacock, Andrew J., Uckan, Aysel, Welsh, David J., Wilson, Kathryn S., Woodward, Rosemary   +14 more
core   +2 more sources

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

B lymphocytes contribute Angiotensin II induced cardiac hypertrophy. [PDF]

Sci Rep
Zhao X, Di X, Wu H, Fang C, Zhu C, Yue T, Zhang D, Jia H, Zhao J, Liang D, Liu J, Gao X, Hao Y.   +12 more
europepmc   +1 more source

Prevention of stillbirths associated with umbilical cord abnormalities: A clinico‐pathological overview

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Stillbirths affect millions of pregnancies every year worldwide, and obstruction of the umbilical cord blood flow is one of the main causes of fetal death. This review provides a clinico‐pathological overview of cord abnormalities potentially associated with antepartum stillbirth, describing the mechanism determining the death and addressing ...
Laura Avagliano, Chiara Parodi, Valentina Massa, Gaetano Bulfamante   +3 more
wiley   +1 more source

Swimming is superior to running in inducing physiological cardiac hypertrophy and enhancing myocardial performance. [PDF]

Sci Rep
Yoshizaki A, Antonio EL, Santos LD, Dos Santos MT, Martins FL, Feliciano RS, Junior JAS, de Melo BL, Bocalini DS, Tucci PJF, Girardi ACC, Serra AJ.   +11 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

USP13-Mediated selective autophagy of eIF5B promotes pathological cardiac hypertrophy. [PDF]

Cell Mol Life Sci
Ye Y, Xu J, Jin C, Li X, Wu X, Zhou C, Gao L, Zhong Z, Li X, Chen S, Wei Y, Peng S, Liu S.   +12 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source