Results 181 to 190 of about 175,167 (244)

Platycodin D alleviates cardiac hypertrophy in the treatment of heart failure by inhibiting p53-dependent BCL-2/Bax/caspase-3 signaling pathway. [PDF]

Front Pharmacol
Li Y, Li H, Liu B, Li Y.
europepmc   +1 more source

Occupational mortality in older workers: A forensic autopsy‐based evaluation

Journal of Forensic Sciences, EarlyView.
Abstract The aging of the global workforce has led to an increasing number of individuals remaining occupationally active at older ages. However, forensic autopsy‐based data on workplace deaths in this population remain limited. This study aimed to evaluate the causes and manners of workplace‐related deaths among individuals aged 65 years and older ...
Muhammet Ali Oruç, Hüseyin Çağrı Şahin, Muhammed Oduncu, Muhammed Fatih Yaman, Abdulkadir Can   +4 more
wiley   +1 more source

Therapeutic Modulation of Mitophagy by Cafestol in Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis. [PDF]

Nutrients
Hao WR, Chen CC, Huang GC, Lin JH, Chen HY, Liu JC, Cheng TH, Chen JJ.   +7 more
europepmc   +1 more source

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

RBMS1 orchestrates cardiac hypertrophy by facilitating CTTN splice-switching and sarcomere dynamics. [PDF]

EMBO Mol Med
Li L, Li T, Wang B, Feng J, Zhang N, Zhang J, Niu Z, Li W, Gao H, Wang Q, Liu Y, Chen Y, Zhang Y, Bian Y, Pan T, Sheng S, Li X, Liu J, Yang B, Liang H.   +19 more
europepmc   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice. [PDF]

Cardiovasc Res
Marino A, Cumps J, Guilbert L, Geiser A, Baufays C, Ginion A, Ferté L, Battault S, De Matos F, Ambroise J, Zuurbier CJ, Lezoualc'h F, Pestiaux C, Pyka G, Kerckhofs G, Roderick HL, Bertrand L, Horman S, Beauloye C.   +18 more
europepmc   +1 more source

Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta‐Analysis

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Dynamic Single Photon Emission Computed Tomography (dynSPECT) is an advanced functional imaging modality that enables estimation of temporal changes in radiopharmaceutical distribution and physiological function. While dynSPECT has been employed in several clinical applications, it has not been widely applied to liver imaging ...
Bader Aloufi, Roger Fulton, Kathy Willowson, Peter L. Kench   +3 more
wiley   +1 more source

Mitophagy in Hypertensive Cardiac Hypertrophy: Mechanisms and Therapeutic Implications. [PDF]

J Clin Hypertens (Greenwich)
Li S, Li X.
europepmc   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source