Results 161 to 170 of about 175,167 (244)

GDF6 Alleviates Pathological Cardiac Hypertrophy via AMPKα Signaling Pathway. [PDF]

Biomedicines
Ren Q, Wang Z, Ren W.
europepmc   +1 more source

MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report

The Laryngoscope, EarlyView.
An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.
Veronica Drozdowski‐Nuccio, Rachel D. Yoon, Steven Tomasi, Dana M. Thompson, Inbal Hazkani   +4 more
wiley   +1 more source

Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes. [PDF]

Front Cardiovasc Med
Zhang Q, Zhao N, Wei S, Lu M, Chen K.
europepmc   +1 more source

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

Tectochrysin alleviates Ang II-induced pathological cardiac hypertrophy by binding to STING and inhibiting STING/NFκB-mediated inflammation. [PDF]

Front Pharmacol
Chen Y, Li F, He Y, Ling Z.
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Cardiac Hypertrophy

, 2007
Thomas Force, Jeffery D. Molkentin
openaire   +2 more sources

Transient elevation in cellular glucose uptake exacerbates pressure overload-induced cardiac hypertrophy and dysfunction. [PDF]

Epigenetics
Bakshi S, Chang SF, Potter LA, Sun Z, Ha CM, Preuss K, Reddy MS, Harrell CA, Chatham JC, Wende AR.   +9 more
europepmc   +1 more source

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

Neuroprotection, EarlyView.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu, Chen Wang, Jinyu Zhu, Jiahui Du, Hao Li, Shuyi Ning, Rui Yang, Yiwen Ma, Mengyuan Yuan, Wei Shen, Huailin Wang, Huihui Jiang, Liping Chen, Haitao Wu   +13 more
wiley   +1 more source

Fructose and salt induce sex- and ovary dependent cardiac hypertrophy in Dahl salt-sensitive rats. [PDF]

Front Cardiovasc Med
Akhtar MA, Ludvigsen S, Mancusi C, de Simone G, Hafstad AD, Gerdts E, Ytrehus K.   +6 more
europepmc   +1 more source