Results 211 to 220 of about 180,059 (262)
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Mechanisms of Cardiac Hypertrophy
Heart Failure Clinics, 2005Cardiac hypertrophy is a response of myocardium to various physiologic and pathologic stimuli, mechanical and hormonal, that causes the heart to work harder under conditions of increased workload [1–3]. Different cardiovascular diseases, such as aortic stenosis, hypertension, and myocardial infarct, cause mechanical stretching on cardiac walls. Cardiac
SELVETELLA, GIULIO, LEMBO, Giuseppe
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Endothelin and Cardiac Hypertrophy
Life Sciences, 1997Cardiac hypertrophy is a commonly observed complication of a variety of cardiovascular diseases. As well as mechanical stresses such as pressure overload, several humoral factors may contribute to the development of cardiac hypertrophy. In the early 1990s, endothelin-1 (ET-1) was found to induce cardiomyocyte hypertrophy in cultured neonatal rat ...
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Catecholamines in cardiac hypertrophy
The American Journal of Cardiology, 1999There has been intense interest in the roles catecholamines may play in compensatory myocardial hypertrophy. This article reviews the following: (1) chronic infusions of catecholamines in experimental animals result in cardiac hypertrophy, but in many of the studies mechanical factors have played a role; (2) experiments using isolated papillary muscles
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Cardiac Hypertrophy in Hypertension
New England Journal of Medicine, 1987Over the past three decades, increasing attention has focused on the hypertensive diseases. During this period, antihypertensive therapy was introduced, and its safety and efficacy were demonstrate...
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Nature Reviews Cardiology, 2020
Gene therapy with H19, a highly conserved long non-coding RNA H19, prevents and reverses pathological cardiac hypertrophy in animal models, according to a study by Thomas Thum and colleagues.
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Gene therapy with H19, a highly conserved long non-coding RNA H19, prevents and reverses pathological cardiac hypertrophy in animal models, according to a study by Thomas Thum and colleagues.
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Experimental Cardiac Hypertrophy
New England Journal of Medicine, 1970STUDIES on the process by which enlargement of the heart occurs1 2 3 4 have been aided by developments in molecular biology.
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Mitochondrial Proliferation in Cardiac Hypertrophy
Basic Research in Cardiology, 1980Mitochondrial proliferation was studied in mature female rats following aortic constriction. Mitochondrial DNA (mtDNA) was assayed by a fluorometric method. The conditions for removal of nuclear DNA were developed and verified by assessment of molecular conformation of DNA.
R, Zak +4 more
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Growth Factor for Cardiac Hypertrophy
Molecular and Cellular Biochemistry, 1993Cardiac size can be regulated by the balance in activity between cardiac growth factors and inhibiting factors, chalones. This study was undertaken to verify the role of the cardiac growth factor and its purification from hypertrophied hearts. For this propose the hypertrophied hearts of renovascular hypertensive rats were used.
M, Nagano +4 more
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Mitochondria and Cardiac Hypertrophy
2017Cardiac tissue responds to long-term hemodynamic load through initiation of a hypertrophic remodeling program. Importantly, if not counteracted this response will eventually lead to organ failure. Cardiac hypertrophic adaptations are complex, and involve multiple cellular events and the mechanisms underlying the development of cardiac hypertrophy are ...
Heberty di Tarso Fernandes, Facundo +3 more
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Cardiac dilatation and hypertrophy
American Heart Journal, 1957Abstract Experimental and clinical evidence contrary to the theory of injury of the heart accompanying dilatation as a cause of cardiac hypertrophy is cited. Results from repetition and extension of the basic experiments from which the theory was launched fail to support the theory.
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