Results 171 to 180 of about 81,793 (267)

Mechanisms of cAMP compartmentation in cardiac myocytes: experimental and computational approaches to understanding. [PDF]

J Physiol, 2021
Harvey RD, Clancy CE.
europepmc   +1 more source

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

The Journal of Physiology, EarlyView.
Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley   +1 more source

Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model. [PDF]

J Gen Physiol
Vysma M, Welsh JS, Laver DR.
europepmc   +1 more source

The Essential Vulnerability of Human Cardiac Myocytes to SARS-CoV-2. [PDF]

JACC Basic Transl Sci, 2021
Das M, Bristow MR, Chung MK.
europepmc   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

FGFR4 Is Required for Concentric Growth of Cardiac Myocytes during Physiologic Cardiac Hypertrophy. [PDF]

J Cardiovasc Dev Dis
Campos I, Richter B, Thomas SM, Czaya B, Yanucil C, Kentrup D, Fajol A, Li Q, Secor SM, Faul C.   +9 more
europepmc   +1 more source

Effects of tamoxifen inducible MerCreMer on gene expression in cardiac myocytes in mice. [PDF]

J Cardiovasc Aging, 2022
Rouhi L, Fan S, Cheedipudi SM, Olcum M, Jeong HH, Zhao Z, Gurha P, Marian AJ.   +7 more
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Mitochondria regulate proliferation in adult cardiac myocytes. [PDF]

J Clin Invest
Waypa GB, Smith KA, Mungai PT, Dudley VJ, Helmin KA, Singer BD, Peek CB, Bass J, Nelson L, Shah SJ, Ofman G, Wasserstrom JA, Muller WA, Misharin AV, Budinger GRS, Abdala-Valencia H, Chandel NS, Dokic D, Bartom E, Zhang S, Tatekoshi Y, Mahmoodzadeh A, Ardehali H, Thorp EB, Schumacker PT.   +24 more
europepmc   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source