Results 11 to 20 of about 81,793 (267)

Paracrine Effects of FGF23 on the Heart

Frontiers in Endocrinology, 2018
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone primarily secreted by osteocytes to maintain phosphate and mineral homeostasis. In patients with and without chronic kidney disease, enhanced circulating FGF23 levels associate with pathologic ...
Maren Leifheit-Nestler, Dieter Haffner
doaj   +1 more source

Silibinin Protects Against Isoproterenol-Induced Rat Cardiac Myocyte Injury Through Mitochondrial Pathway After Up-regulation of SIRT1

Journal of Pharmacological Sciences, 2006
Terminally differentiated adult injured cardiac myocytes have been used for various animal models of heart failure. It has recently been shown that isoproterenol induces injury in rat neonatal cardiac myocytes via a β-adrenergic pathway, suggesting that ...
Bei Zhou, Li-Jun Wu, Lin-Hao Li, Shin-ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejima   +6 more
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C-reactive protein inhibits survivin expression via Akt/mTOR pathway downregulation by PTEN expression in cardiac myocytes. [PDF]

PLoS ONE, 2014
C-reactive protein (CRP) is one of the most important biomarkers for arteriosclerosis and cardiovascular disease. Recent studies have shown that CRP affects cell cycle and inflammatory process in cardiac myocytes.
Beom Seob Lee, Soo Hyuk Kim, Jaewon Oh, Taewon Jin, Eun Young Choi, Sungha Park, Sang-Hak Lee, Ji Hyung Chung, Seok-Min Kang   +8 more
doaj   +1 more source

Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants

Antioxidants, 2021
Homeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling ...
Sun-Hee Woo, Joon-Chul Kim, Nipa Eslenur, Tran Nguyet Trinh, Long Nguyen Hoàng Do   +4 more
doaj   +1 more source

Calcium Signaling in Cardiac Myocytes [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Calcium (Ca(2+)) is a critical regulator of cardiac myocyte function. Principally, Ca(2+) is the link between the electrical signals that pervade the heart and contraction of the myocytes to propel blood. In addition, Ca(2+) controls numerous other myocyte activities, including gene transcription.
Fearnley, Claire J., Roderick, H. Llewelyn, Bootman, Martin D.   +2 more
openaire   +2 more sources

Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro.

PLoS ONE, 2009
BackgroundMammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Carmen H Coxon, Katrina A Bicknell, Fleur L Moseley, Gavin Brooks   +3 more
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Unusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat

European Journal of Histochemistry, 2012
TRPV4 protein forms a Ca2+-permeable channel that is sensitive to osmotic and mechanical stimuli and responds to warm temperatures, and expresses widely in various kinds of tissues.
Y. Zhao, H. Huang, Y. Jiang, H. Wei, P. Liu, W. Wang, W. Niu   +6 more
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PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.

PLoS ONE, 2010
To identify novel transmembrane and secretory molecules expressed in cardiac myocytes, signal sequence trap screening was performed in rat neonatal cardiac myocytes.
Koji Isodono, Tomosaburo Takahashi, Hiroko Imoto, Naohiko Nakanishi, Takehiro Ogata, Satoshi Asada, Atsuo Adachi, Tomomi Ueyama, Hidemasa Oh, Hiroaki Matsubara   +9 more
doaj   +1 more source

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

JACC: Basic to Translational Science, 2016
Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy, exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism has not been elucidated.
Kurt W. Prins, MD, PhD, Michelle L. Asp, PhD, Huiliang Zhang, PhD, Wang Wang, MD, PhD, Joseph M. Metzger, PhD   +4 more
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De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges

Stem Cells International, 2017
The advent of cellular reprogramming technology has revolutionized biomedical research. De novo human cardiac myocytes can now be obtained from direct reprogramming of somatic cells (such as fibroblasts), from induced pluripotent stem cells (iPSCs, which
Veronique Hamel, Kang Cheng, Shudan Liao, Aizhu Lu, Yong Zheng, Yawen Chen, Yucai Xie, Wenbin Liang   +7 more
doaj   +1 more source