Results 31 to 40 of about 93,083 (312)
The Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes
Scientific Reports, 2021 Inducing cardiac myocytes to proliferate is considered a potential therapy to target heart disease, however, modulating cardiac myocyte proliferation has proven to be a technical challenge.
Abigail C. Neininger +3 more
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Polyploidization of transplanted cardiac myocytes [PDF]
Cell Differentiation and Development, 1988 Pieces of cardiac ventricular tissue of late embryonic or 1-day postnatal rats, implanted beneath the kidney capsule of adult syngeneic hosts, formed viable, beating transplants. These transplants were investigated over a 40-day postoperative course. In the transplants, cellular binucleation and nuclear polyploidization occurred according to the same ...
Brodsky, V. Ya. +3 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2008 It has been suggested that a new type of large-conductance Ca2+-activated K+ (BK) channel is distributed in the inner mitochondrial membrane (mitoKCa channel) and that its opening may attenuate ischemic cardiac injury.
Kazuho Sakamoto +3 more
doaj +1 more source
Epigenetic regulation of cardiac myocyte differentiation†[PDF]
Frontiers in Genetics, 2014 Cardiac myocytes (CMs) proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation. This cell cycle exit is associated with the upregulation of a host of adult cardiac-specific genes.
Oyama, Kyohei +4 more
openaire +3 more sources
Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes [PDF]
, 2012 Background and aim: Human atrial transient outward K+ current (ITO) is decreased in a variety of cardiac pathologies, but how ITO reduction alters action potentials (AP) and arrhythmia mechanisms is poorly understood, owing to non-selectivity of ITO ...
Marshall, G.E. +4 more
core +1 more source
Cellular Physiology of Rat Cardiac Myocytes in Cardiac Fibrosis: In Vitro Simulation Using the Cardiac Myocyte/Cardiac Non-Myocyte Co-Culture System [PDF]
Hypertension Research, 2008 An understanding of the cellular physiology of cardiac myocytes (MCs) and non-myocytes (NMCs) may help to explain the mechanisms underlying cardiac hypertrophy. Despite numerous studies using MC/NMC co-culture systems, it is difficult to precisely evaluate the influence of each cell type because of the inherent cellular heterogeneity of such a system ...
Keiichi, Ikeda +9 more
openaire +2 more sources
Alexandria Journal of Medicine, 2016 The calcium signaling plays a crucial role in expansion and contraction of cardiac myocytes. This calcium signaling is achieved by calcium diffusion, buffering mechanisms and influx in cardiac myocytes.
Kunal Pathak, Neeru Adlakha
doaj +1 more source
Modeling the isolated cardiac myocyte
Progress in Biophysics and Molecular Biology, 2004 Computer modeling of cardiac myocytes has flourished in recent years. Models have evolved from mathematical descriptions of ionic channels alone to more sophisticated formulations that include calcium transport mechanisms, ATP production and metabolic pathways. The increased complexity is fueled by the new data available in the field.
Jose L, Puglisi +2 more
openaire +2 more sources
The Unmasking Effect: Propofol-Induced Brugada Pattern in a Critically Ill Patient
Case Reports in Cardiology, 2022 Brugada syndrome is a known cause of dysrhythmias and sudden cardiac death. It is linked to mutations in myocardial sodium channel leading to hyperexcitable cardiac myocytes.
Esiemoghie Akhigbe +4 more
doaj +1 more source
Gene Transfer into Cardiac Myocytes [PDF]
, 2015 Traditional methods for DNA transfection are often inefficient and toxic for terminally differentiated cells, such as cardiac myocytes. Vector-based gene transfer is an efficient approach for introducing exogenous cDNA into these types of primary cell cultures.
Sarah E, Lang, Margaret V, Westfall
openaire +2 more sources