Results 241 to 250 of about 93,083 (312)
The Journal of Physiology, EarlyView.Abstract figure legend Activation time (AT) maps from right ventricular apical pacing in a human ventricles model with longer action potential duration in the His‐Purkinje system (HPS) than in the myocardium (MYO). For pacing with a long S1S2 coupling interval (CI), the AT from the myocardial pacing site to the first AT of the HPS (ATMYO) is longer ...
Jason D. Bayer +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid +17 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Comparative multimodal calibration of patient‐specific left atrial (LA) models to identify arrhythmogenic substrates in atrial fibrillation (AF). A, LA models shown in posterior and anterior views, calibrated separately using: late gadolinium enhancement magnetic resonance imaging (LGE‐MRI) image intensity ratio (IIR; blue–red ...
Mahmoud Ehnesh +14 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
wiley +1 more source
A microstructurally motivated framework to study autoregulation in the coronary circulation
The Journal of Physiology, EarlyView.Abstract figure legend A microstructurally motivated framework was constructed to simulate coronary autoregulation in symmetrically bifurcating trees at three myocardial depths: subepicardial (subepi), midwall and subendocardial (subendo). Wall mechanics of individual vessels are governed by a constrained‐mixture model, incorporating elastin, collagen ...
Matthew J. Eden +8 more
wiley +1 more source
hERG1 channels and potential therapeutics for long QT syndrome
The Journal of Physiology, EarlyView.Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider +3 more
wiley +1 more source
CaV1.2 dynamics in native male arterial myocytes
The Journal of Physiology, EarlyView.Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel +9 more
wiley +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg +9 more
wiley +1 more source
Effect of Tokishakuyakusan on Anemia in a Rat Model of Salt‐Sensitive Hypertension
Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.ABSTRACT Aim Anemia is prevalent in patients with cardiac and renal diseases and is associated with morbidity and mortality. Consequently, new strategies for managing anemia are expected in these patients. Tokishakuyakusan, a Kampo medicine, is clinically used to treat various conditions, such as anemia and chronic nephritis.
Yoshiro Naito +3 more
wiley +1 more source