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Mechanotransduction in Cardiac Myocytes
Annals of the New York Academy of Sciences, 2004Abstract: Cardiac myocytes react to diverse mechanical demands with a multitude of transient and long‐term responses to normalize the cellular mechanical environment. Several stretch‐activated signaling pathways have been identified, most prominently guanine nucleotide binding proteins (G‐proteins), mitogen‐activated protein kinases (MAPK), Janus ...
Jan, Lammerding +2 more
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Ephaptic Coupling in Cardiac Myocytes
IEEE Transactions on Biomedical Engineering, 2013While it is widely believed that conduction in cardiac tissue is regulated by gap junctions, recent experimental evidence suggests that the extracellular space may play a significant role in action potential propagation. Cardiac tissue with low gap junctional coupling still exhibits conduction, with conflicting degrees of slowing that may be due to ...
Joyce Lin, James P. Keener
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Lateral Membrane-Specific MAGUK CASK Down-Regulates Na V 1.5 Channel in Cardiac Myocytes
Circulation Research, 2016 RATIONALE Mechanisms underlying membrane protein localization are crucial in the proper function of cardiac myocytes. The main cardiac sodium channel, NaV1.5, carries the sodium current (INa) that provides a rapid depolarizing current during the ...
Jean-Sébastien Rougier +2 more
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Commitment and differentiation of cardiac myocytes
Trends in Cardiovascular Medicine, 1992This article reviews what is known about the earliest stages of heart development focusing on the periods of commitment and differentiation of cardiac progenitor cells and their molecular regulation. The pathway from precursor to differentiated cardiac myocyte is crucial to forming a normal, functional heart.
J, Litvin +4 more
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Surface cables of cardiac myocytes
Journal of Molecular and Cellular Cardiology, 1980Abstract Heart muscle cells prepared by mechanical disaggregation were seen by transmission electron microscopy (TEM) to possess an intact glycocalyx. Scanning electron microscopy (SEM) studies of the surface of these cells revealed longitudinally oriented cables, 10 to 12 nm thick.
J, Orenstein, D, Hogan, S, Bloom
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Myocyte Growth and Cardiac Repair
Journal of Molecular and Cellular Cardiology, 2002Introduced several decades ago, the dogma persists that ventricular myocytes are terminally differentiated cells and cardiac repair by myocyte regeneration is completely inhibited shortly after birth. On the basis that cardiac myocytes are unable to divide in the adult heart, myocyte growth under physiologic and pathologic conditions is believed to be ...
Piero, Anversa +3 more
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Microtubules in Cardiac Myocytes
1988Publisher Summary This chapter describes the distribution of microtubules (MTs) in various physiopathological states and of their involvement in a broad spectrum of cellular processes. MTs, like actin filaments, are made up of globular protein subunits that can assemble and disassemble rapidly in the cell.
L, Rappaport, J L, Samuel
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Regulation of glutathione in cardiac myocytes
Journal of Molecular and Cellular Cardiology, 2003Reduced glutathione (GSH) is an essential, multifunctional tripepetide that controls redox-sensitive cellular processes, but its regulation in the heart is poorly understood. The present study used a pharmocological model of GSH depletion to examine cellular mechanisms controlling cardiac GSH. Inhibition of GSH metabolism was elicited in normal rats by
Shumin, Li, Xun, Li, George J, Rozanski
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