Results 281 to 290 of about 93,083 (312)
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Molecular mechanisms of apoptosis in the cardiac myocyte
Current Opinion in Pharmacology, 2001Cardiac myocytes can undergo programmed cell death in response to a variety of insults and apoptotic elimination of myocytes from the adult myocardium can lead directly to cardiomyopathy and death. Although it remains to be shown that therapy specifically targeting apoptosis will improve the prognosis of ischemic heart disease or heart failure, a ...
N H, Bishopric +3 more
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Cardiac myocytes and the cardiac action potential
2010Cardiac myocytes are the contractile cells of the heart and constitute the bulk of heart mass. There are differences between the myocytes of the ventricles, the atria, and the conduction system: ventricular myocytes are elongated cells and packed with myofibrils (the contractile apparatus) and mitochondria (for ATP production)....
Kenneth T. MacLeod +4 more
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Simplified Models for Electromechanics of Cardiac Myocyte
2020The study of the electromechanical activity of the heart through computational models is important for the interpretation of several cardiac phenomena. However, computational models for this purpose can be computationally expensive. In this work, we present the simplified models at the cellular level which were able to qualitatively reproduce the ...
João Gabriel Rocha Silva +3 more
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Leptofibrils in Cardiac Myocytes
Ultrastructural Pathology, 1988Eloisa Arbustini +3 more
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Autophagy in cardiac myocytes.
Recent advances in studies on cardiac structure and metabolism, 1978The fetal mouse heart (FMH) in organ culture continues to beat for a period of weeks, but degenerative changes occur. Electron microscopy revealed formation of autophagic vacuoles containing damaged organelles in some cells after the first day, indicating focal cytoplasmic injury.
H D, Sybers, J, Ingwall, M, DeLuca
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Nuclear ion channels in cardiac myocytes
Pfl�gers Archiv European Journal of Physiology, 1992The paradigm that nucleocytoplasmic transport of ions occurs without a diffusional barrier has been challenged by the recent demonstration with patch-clamp techniques of the existence of ion channels in the nuclear envelope of murine zygotes and hepatocytes.
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Anoxic injury of adult cardiac myocytes
1984Cultured adult cardiocytes were exposed to anoxia. The initial decrease of high-energy phosphates was accompanied by a moderate release of cytosolic enzymes and morphological changes: the appearance of sarcolemmal 'microblebs' (approximately 1 micron in diameter) and an increase of subsarcolemmal vesicles. At ATP levels above 2 mumol/gww, metabolic and
H M, Piper +4 more
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An overview of endothelin signaling in the cardiac myocyte
Journal of Molecular and Cellular Cardiology, 2003Three endothelin (ET) isopeptides have been identified: ET-1, ET-2 and ET-3. These have two well-established gross effects on the cardiac myocyte. They affect the contractile properties and they stimulate myocyte growth and myofibrillogenesis. There may be other effects that are less fully characterized (e.g. increased resistance apoptosis).
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