Results 161 to 170 of about 51,089 (251)
Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
Advanced Genetics, Volume 7, Issue 2, June 2026.This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains unclear. This study aims to identify a deubiquitinase (DUB)
Jongbeom Chae +9 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.ABSTRACT Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age‐related deterioration.
So Jeong Park +15 more
wiley +1 more source
Post Activation Potentiation Is Greater in Human Triceps Brachii Versus Triceps Surae Muscles
Muscle &Nerve, Volume 73, Issue 5, Page 815-821, May 2026.ABSTRACT Introduction/Aims Voluntary muscle contractions result in a temporary increase in twitch force, a phenomenon termed post activation potentiation (PAP). In rodents and other species, PAP is observed predominantly or exclusively in fast twitch muscles. However, it has been suggested that in humans, PAP occurs more or less independently of muscle
William S. Zoughaib +4 more
wiley +1 more source
UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia
Aging Cell, Volume 25, Issue 5, May 2026.Aging reduces Unc45b expression in fast‐twitch muscle, concomitant with reduction in muscle contractile capacity and muscle mass in mice. Unc45b deficiency initially reduces depolarization‐induced force, followed by a decline in fast‐twitch muscle mass in adult mice.
Taiga Mishima +17 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter +3 more
wiley +1 more source
SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
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Experimental Physiology, Volume 111, Issue 5, Page 2599-2612, 1 May 2026.Abstract A decrease in resting muscle O2 uptake (V̇O2m${\dot V_{{{\mathrm{O}}_2}{\mathrm{m}}}}$) described during bed rest (BR) could determine a decreased whole‐body resting energy expenditure (REE), potentially useful during prolonged spaceflights. Two groups of recreationally active men (young [Y], n = 8, age 23 ± 5 years; elderly [E], n = 10, age ...
Giovanni Baldassarre +14 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Ischaemic/hypoxic stress leads to heart remodeling and dysfunction. PCYOX1 promotes cardiomyocyte survival during injury, reducing the generation of reactive oxygen species. PCYOX1 deficiency regulates key proteins to preserve cardiomyocyte structure and function such as creatine kinase.
Cristina Banfi +5 more
wiley +1 more source