Results 221 to 230 of about 51,825 (261)
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Two cardiac myosin inhibitors in the treatment of obstructive hypertrophic cardiomyopathy
MedA key area of therapeutic progress in obstructive hypertrophic cardiomyopathy revolves around the emergence of cardiac myosin inhibitors, of which mavacamten and aficamten represent the first and second molecules. We summarize the key research evidence, including many similarities and potential differences between various clinical trials studying these
Milind Y, Desai, Eugene, Braunwald
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The Revolution of Cardiac Myosin Inhibitors in Patients With Hypertrophic Cardiomyopathy
Canadian Journal of CardiologyHypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy worldwide and causes significant morbidity and mortality. For decades, medical treatment options have been limited and untargeted, with frequent need for invasive interventions not readily accessible to many HCM patients.
Rebecca Haraf, Hany Habib, Ahmad Masri
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Recent trend in the therapy of hypertrophic cardiomyopathy: Cardiac myosin inhibitors
2023Cardiac myosin inhibitors are a new class of drugs that have recently been approved in obstructive hypertrophic cardiomyopathy. The main mechanism of action is to reduce the pathologically increased cardiac hypercontractility. Current drug therapies have not been demonstrated to modify the natural progress of the disease.
DEMİRKIRAN, Cahit +2 more
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Cardiac Myosin Inhibitors for Managing Obstructive Hypertrophic Cardiomyopathy
JACC: Heart Failure, 2023John W. Ostrominski +3 more
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Heart of the matter: A GP’s guide to cardiac myosin inhibitors
InnovAiT: Education and inspiration for general practiceHypertrophic obstructive cardiomyopathy (HOCM) is a heritable heart condition. It causes hypertrophy of the heart muscle and left ventricular outflow tract obstruction. Hypertrophic cardiomyopathy (HCM) is one of the most prevalent inherited cardiac disorders, with more than 1400 mutations discovered.
Tamara Naneishvili +8 more
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FDA approves first cardiac myosin inhibitor
Nature Reviews Drug Discovery, 2022openaire +1 more source
Cardiac Myosin Inhibitors: Unlocking Potential to Improve Treatment in Hypertrophic Cardiomyopathy
Circulation, 2023Aslan Teyfik Turer, Andrew Wang
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Cardiac Myosin Inhibitors for Obstructive Hypertrophic Cardiomyopathy
Journal of the American College of Cardiology, 2022openaire +1 more source