Results 21 to 30 of about 1,444,670 (278)

Identification of functional differences between recombinant human ? and ? cardiac myosin motors [PDF]

, 2012
The myosin isoform composition of the heart is dynamic in health and disease and has been shown to affect contractile velocity and force generation.
Rezavandi, Heresh, Rezavandi, H., Leslie A. Leinwand, Geeves, M., Leinwand, Leslie A., Leinwand, L., Geeves, Michael A., Marieke J. Bloemink, Heresh Rezavandi, Deacon, John C., Bloemink, Marieke J., Deacon, J., John C. Deacon, Bloemink, M., Michael A. Geeves   +14 more
core   +1 more source

A New Chapter in the Management of Hypertrophic Cardiomyopathy: Cardiac Myosin Inhibitors [PDF]

Cardiologia Hungarica, 2023
In the recent years, there has been a significant breakthrough in the treatment of hypertrophic cardiomyopathy. New precision molecules have been developed and successfully applied in clinical trials. A new class of orally available allosteric inhibitors reduces heart muscle hypercontractility, the core molecular defect of the disease, by selectively ...
Pálinkás, Eszter Dalma, Sepp, Róbert, Olivotto, Iacopo   +2 more
openaire   +2 more sources

Cardiac myosin contraction and mechanotransduction in health and disease [PDF]

, 2021
Cardiac myosin is the molecular motor that powers heart contraction by converting chemical energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly regulated to meet the physiological needs of the body. Recent multiscale
Barrick, Samantha K, Greenberg, Michael J, Samantha K. Barrick, Michael J. Greenberg   +3 more
core   +1 more source

Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin Head [PDF]

, 2009
We investigated the biochemical and biophysical properties of one of the four alternative regions within the Drosophila myosin catalytic domain: the relay domain encoded by exon 9.
Girish C. Melkani, Bernstein, Sanford I., Corey M. Dambacher, Geeves, M., Melkani, Girish C., Knowles, Aileen F., Geeves, Michael A., Marieke J. Bloemink, Aileen F. Knowles, Melanki, G., Bloemink, Marieke J., Bloemink, M., Bernstein, S., Sanford I. Bernstein, Dambacher, C., Knowles, A., Dambacher, Corey M., Michael A. Geeves   +17 more
core   +1 more source

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion [PDF]

, 2014
This work was supported by US Public Health Service grant AI054961 (GEW/NJW), a University Research Fellowship from the Royal Society (NJW) and funding for the mass spectrometry analysis was provided by the Vermont Genetics Network/NIH Grant 8P20GM103449
Pathak, R.B., Bryan A. Ballif (238963), Nicholas J Westwood, Westwood, N.J., Gary E Ward, Leung, J.M., Jacqueline M Leung, Poupart, S., Ward, G.E., Nicholas J. Westwood (254891), Séverine Poupart (571871), Gary E. Ward (208054), Ballif, B.A., Séverine Poupart, Tran, F., Aoife T. Heaslip (207534), Bryan A Ballif, Fanny Tran, Aoife T Heaslip, Fanny Tran (571869), Jacqueline M. Leung (120235), Heaslip, A.T., Ravindra B Pathak, Ravindra B. Pathak (571870), Ballif Bryan A., Westwood Nicholas J., Tran Fanny, Pathak Ravindra B., Leung Jacqueline M., Poupart Séverine, Ward Gary E., Heaslip Aoife T., Westwood, N.J.; id_orcid   +32 more
core   +2 more sources

AZD2014, a dual mTOR inhibitor, attenuates cardiac hypertrophy in vitro and in vivo

Journal of Biological Engineering, 2021
Cardiac hypertrophy is one of the most common genetic heart disorders and considered a risk factor for cardiac morbidity and mortality. The mammalian target of rapamycin (mTOR) pathway plays a key regulatory function in cardiovascular physiology and ...
Byung-Hyun Cha, Minjin Jung, Angela S. Kim, Victoria C. Lepak, Brett A. Colson, David A. Bull, Youngwook Won   +6 more
doaj   +1 more source

Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1

Cardiovascular Therapeutics, 2021
Ginkgolide B (GB) is an active ingredient extracted from Ginkgo biloba leaves. However, the effects of GB on cardiac hypertrophy remain unclear. The study is aimed at determining whether GB could alleviate cardiac hypertrophy and exploring its underlying
Qingyuan Jiang, Ming Lu, Jinyu Li, Zhongsheng Zhu   +3 more
doaj   +1 more source

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity [PDF]

, 2010
Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L., Federica Catti, David M Warshaw, Nicholas J Westwood, Catti, Federica, Gary E Ward, Jacqueline M Leung, Kimberly L Carey, Leung, Jacqueline M., Warshaw, David M., Ballif, Bryan A., Heaslip, Aoife T., Bryan A Ballif, Westwood, Nicholas J., Ward, Gary E., Aoife T Heaslip, Catti Federica, Leung Jacqueline M., Carey Kimberly L., Warshaw David M., Ballif Bryan A., Westwood Nicholas J., Ward Gary E., Heaslip Aoife T., Westwood, Nicholas J.; id_orcid   +24 more
core   +2 more sources

RIP1/RIP3/MLKL Mediates Myocardial Function Through Necroptosis in Experimental Autoimmune Myocarditis

Frontiers in Cardiovascular Medicine, 2021
Cardiomyopathy often leads to dilated cardiomyopathy (DCM) when caused by viral myocarditis. Apoptosis is long considered as the principal process of cell death in cardiomyocytes, but programmed necrosis or necroptosis is recently believed to play an ...
Yujing Wu, Yujing Wu, Yujing Wu, Zhenzhong Zheng, Zhenzhong Zheng, Xiantong Cao, Qing Yang, Qing Yang, Vikram Norton, Avner Adini, Amit K. Maiti, Irit Adini, Hao Wu   +12 more
doaj   +1 more source

Novel Cardiac Myosin Inhibitor Therapy for Hypertrophic Cardiomyopathy in Adults: A Contemporary Review. [PDF]

Am J Cardiovasc Drugs
Hypertrophic cardiomyopathy (HCM) affects as many as 1 in 200 people in the adult population globally. Patients may present with exertional dyspnea, presyncope or syncope, atrial and ventricular arrhythmias, heart failure, and even sudden cardiac death.
Kalinski JK, Xu B, Boyd R, Tasseff N, Rutkowski K, Ospina S, Smedira N, Thamilarasan M, Popovic ZB, Desai MY.   +9 more
europepmc   +3 more sources