Results 21 to 30 of about 26,699 (253)

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy

, 2021
Hypercontractility of the cardiac sarcomere may be essential for the underlying pathological hypertrophy and fibrosis in genetic hypertrophic cardiomyopathies.
Chihyuan Chuang (3742285), Luke Ashcraft (11520561), Yangsong Wu (11520570), Eddie Wehri (10974640), Laura A. Robertson (11520582), Jeanelle Zamora (11520579), Peadar Cremin (11520576), Fady I. Malik (324328), Mark Vander Wal (11520564), Bradley P. Morgan (2245510), Darren T. Hwee (11520567), Julia Schaletzky (4923427), James Hartman (2245495), Scott Collibee (2245519), Xiaolin Wang (303612), Eva R. Chin (11520573), Jingying Wang (4458820), Wenyue Wang (627186)   +17 more
core   +4 more sources

Development and prevention of ischemic contracture (“stone heart”) in the pig heart

Frontiers in Cardiovascular Medicine, 2023
Stone heart (ischemic contracture) is a rare and serious condition observed in the heart after periods of warm ischemia. The underlying mechanisms are largely unknown and treatment options are lacking.
Mei Li, Mei Li, Zhi Qin, Erik Steen, Ann Terry, Bowen Wang, Björn Wohlfart, Stig Steen, Anders Arner   +8 more
doaj   +1 more source

Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers

Frontiers in Physiology, 2020
It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal fast-twitch and cardiac muscle preparations. This behavior has not been studied in human muscle fibers
Alfredo Jesus López-Dávila, Joseph M. Chalovich, Stefan Zittrich, Birgit Piep, Faramarz Matinmehr, Andras Málnási-Csizmadia, Anna Á. Rauscher, Theresia Kraft, Bernhard Brenner, Robert Stehle   +9 more
doaj   +1 more source

Long-Term Follow-Up After Discontinuation of Mavacamten in Hypertrophic Obstructive CardiomyopathyNovel Teaching Points [PDF]

CJC Open
Mengdi Yu, BMSc, Fang Wang, BMSc, Lutong Pu, MSc, Jie Wang, MD, Yucheng Chen, MD   +4 more
doaj   +2 more sources

AZD2014, a dual mTOR inhibitor, attenuates cardiac hypertrophy in vitro and in vivo

Journal of Biological Engineering, 2021
Cardiac hypertrophy is one of the most common genetic heart disorders and considered a risk factor for cardiac morbidity and mortality. The mammalian target of rapamycin (mTOR) pathway plays a key regulatory function in cardiovascular physiology and ...
Byung-Hyun Cha, Minjin Jung, Angela S. Kim, Victoria C. Lepak, Brett A. Colson, David A. Bull, Youngwook Won   +6 more
doaj   +1 more source

Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1

Cardiovascular Therapeutics, 2021
Ginkgolide B (GB) is an active ingredient extracted from Ginkgo biloba leaves. However, the effects of GB on cardiac hypertrophy remain unclear. The study is aimed at determining whether GB could alleviate cardiac hypertrophy and exploring its underlying
Qingyuan Jiang, Ming Lu, Jinyu Li, Zhongsheng Zhu   +3 more
doaj   +1 more source

A New Chapter in the Management of Hypertrophic Cardiomyopathy: Cardiac Myosin Inhibitors [PDF]

Cardiologia Hungarica, 2023
In the recent years, there has been a significant breakthrough in the treatment of hypertrophic cardiomyopathy. New precision molecules have been developed and successfully applied in clinical trials. A new class of orally available allosteric inhibitors reduces heart muscle hypercontractility, the core molecular defect of the disease, by selectively ...
Pálinkás, Eszter Dalma, Sepp, Róbert, Olivotto, Iacopo   +2 more
openaire   +2 more sources

RIP1/RIP3/MLKL Mediates Myocardial Function Through Necroptosis in Experimental Autoimmune Myocarditis

Frontiers in Cardiovascular Medicine, 2021
Cardiomyopathy often leads to dilated cardiomyopathy (DCM) when caused by viral myocarditis. Apoptosis is long considered as the principal process of cell death in cardiomyocytes, but programmed necrosis or necroptosis is recently believed to play an ...
Yujing Wu, Yujing Wu, Yujing Wu, Zhenzhong Zheng, Zhenzhong Zheng, Xiantong Cao, Qing Yang, Qing Yang, Vikram Norton, Avner Adini, Amit K. Maiti, Irit Adini, Hao Wu   +12 more
doaj   +1 more source

Dissecting the roles of mTORC1 and mTORC2 in the mouse heart [PDF]

, 2013
Mammalian target of rapamycin (mTOR) is an evolutionary conserved serine/threonine kinase that regulates cell growth and metabolism. mTOR occurs in cells in two complexes, termed mTORC1 and mTORC2.
Shende, Pankaj
core   +1 more source

Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy. [PDF]

PLoS ONE, 2016
Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein family, responsible for the transportation of fatty acids.
Ji Zhang, Congzhen Qiao, Lin Chang, Yanhong Guo, Yanbo Fan, Luis Villacorta, Y Eugene Chen, Jifeng Zhang   +7 more
doaj   +1 more source