Results 51 to 60 of about 1,444,670 (278)

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Frontiers in Cardiovascular Medicine, 2020
Background: Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that is involved in several functions including the deamination of adenosine to inosine, RNA interference (RNAi) mechanisms and microRNA (miRNA) processing ...
Hamid el Azzouzi, Hamid el Azzouzi, Andreia P. Vilaça, Dries A. M. Feyen, Willemijn M. Gommans, Roel A. de Weger, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Joost P. G. Sluijter, Joost P. G. Sluijter, Joost P. G. Sluijter   +11 more
doaj   +1 more source

Mavacamten stabilizes the auto-inhibited state of two-headed cardiac myosin

, 2018
We used transient biochemical and structural kinetics to elucidate the molecular mechanism of mavacamten, an allosteric cardiac myosin inhibitor and prospective treatment for hypertrophic cardiomyopathy.
John A. Rohde, David D. Thomas, Joseph M. Muretta   +2 more
core   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids

Cells
MYBPC3, encoding cardiac myosin binding protein-C (cMyBP-C), is the most mutated gene known to cause hypertrophic cardiomyopathy (HCM). However, since little is known about the underlying etiology, additional in vitro studies are crucial to defining the ...
Darshini Desai, Taejeong Song, Rohit R. Singh, Akhil Baby, James McNamara, Lisa C. Green, Pooneh Nabavizadeh, Mark Ericksen, Sholeh Bazrafshan, Sankar Natesan, Sakthivel Sadayappan   +10 more
doaj   +1 more source

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source

The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac beta-Myosin

, 2014
The human hypertrophic cardiomyopathy mutation R453C results in one of the more severe forms of the myopathy. Arg-453 is found in a conserved surface loop of the upper 50-kDa domain of the myosin motor domain and lies between the nucleotide binding ...
Geeves, M., Leinwand, Leslie A., Combs, A., Geeves, Michael A., Vera, Carlos, Combs, Ariana, Deacon, John C., Bloemink, Marieke J., Langer, Stephen, Deacon, J., Vera, C., Bloemink, M., Langer, S., Leindwand, L.   +13 more
core   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Alcohol septal ablation in hypertrophic cardiomyopathy: For which patients?

ESC Heart Failure, 2023
Percutaneous and surgical therapies for septal reduction for hypertrophic cardiomyopathy have been going head‐to‐head for the past 20 years with similar outcomes and mortality rates, although contemporary myectomy seems to materialize its superiority ...
Alexandru Achim, Adela Mihaela Serban, Stefan Dan Cezar Mot, Gregor Leibundgut, Madalin Marc, Ulrich Sigwart   +5 more
doaj   +1 more source

Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies

, 2008
Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen in animal models of myocarditis and is released from the ...
Olansky, Leann, Adita Mascaro-Blanco, David C. Kem, Cunningham, Madeleine W, Janet S. Heuser, Timothy Lyons, Carl J. Rubenstein, Yu, Xichun, Lyons, Timothy, David Duvall, Mascaro-Blanco, Adita, Leann Olansky, Rubenstein, Carl J, Kem, David C, Lindenfeld, JoAnn, Cooper, Leslie T, Xichun Yu, Gosmanova, Albina, Alvarez, Kathy, JoAnn Lindenfeld, Leslie T. Cooper, Albina Gosmanova, Heuser, Janet S, Kathy Alvarez, Duvall, David, Madeleine W. Cunningham   +25 more
core   +1 more source

Cryo-EM structure of the human cardiac myosin filament

, 2023
Pumping of the heart is powered by filaments of the motor protein myosin that pull on actin filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac myosin-binding protein C (cMyBP-C), which modulates contractility ...
Padrón, Raúl, Dutta, Debabrata, Campbell, Kenneth S, Nguyen, Vu, Craig, Roger   +4 more
core   +1 more source