Results 51 to 60 of about 51,089 (251)

Efficacy of cardiac myosin inhibitors mavacamten and aficamten in hypertrophic cardiomyopathy: a systematic review and meta-analysis of randomised controlled trials

Open Heart
Background Unlike other suggested therapies, myosin inhibitors have been shown to change the course of hypertrophic cardiomyopathy by altering the contractile mechanics of cardiomyocytes.
Ayesha Aman, Arfa Akram, Bisma Akram, Momina Maham, Masooma Zainab Bokhari, Aleena Akram, Sania Akram, Furqan Yaqub   +7 more
doaj   +1 more source

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

Frontiers in Cardiovascular Medicine, 2020
Background: Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that is involved in several functions including the deamination of adenosine to inosine, RNA interference (RNAi) mechanisms and microRNA (miRNA) processing ...
Hamid el Azzouzi, Hamid el Azzouzi, Andreia P. Vilaça, Dries A. M. Feyen, Willemijn M. Gommans, Roel A. de Weger, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Pieter A. F. Doevendans, Joost P. G. Sluijter, Joost P. G. Sluijter, Joost P. G. Sluijter   +11 more
doaj   +1 more source

Progress in New Therapies Targeting the Pathogenesis of Cardiomyopathywith Hypertrophic Phenotype

罕见病研究, 2023
Hypertrophic cardiomyopathy (HCM) is cardiomyopathy with a clinical phenotype of cardiac hypertrophy. The etiology includes genetically defective encoding sarcomeres, congenital metabolic diseases such as lysosomal storage diseases, systemic amyloidosis ...
LIU Yanbo, TIAN Zhuang, ZHANG Shuyang
doaj   +1 more source

Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States

Journal of Molecular Biology, 2021
In addition to a conventional relaxed state, a fraction of myosins in the cardiac muscle exists in a low-energy consuming super-relaxed (SRX) state, which is kept as a reserve pool that may be engaged under sustained increased cardiac demand. The conventional relaxed and the super-relaxed states are widely assumed to correspond to a structure where ...
Sampath K, Gollapudi, Weikang, Ma, Srinivas, Chakravarthy, Ariana C, Combs, Na, Sa, Stephen, Langer, Thomas C, Irving, Suman, Nag   +7 more
openaire   +2 more sources

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. [PDF]

, 2016
BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Bopassa, Jean C, Centala, Alexander, Eghbali, Mansoureh, Iorga, Andrea, Li, Jingyuan, Nadadur, Rangarajan D, Ren, Shuxun, Saito, Tomoaki, Sharma, Salil, Stefani, Enrico, Toro, Ligia, Umar, Soban, Wang, Yibin   +12 more
core   +1 more source

Cardiac Myosin Inhibition for Treatment of LVOT Obstruction in a Patient With Severe AS

JACC: Case Reports
Aortic stenosis and obstructive hypertrophic cardiomyopathy are common conditions. When both are present in the same patient, the management can be challenging.
Ronald H. Wharton, MD, Elana Koss, MD, Bruce Rutkin, MD, Robert S. Palazzo, MD, Jeffrey T. Kuvin, MD   +4 more
doaj   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. [PDF]

, 2018
FRET-based biosensor experiments in adult cardiomyocytes are a powerful way of dissecting the spatiotemporal dynamics of the complicated signaling networks that regulate cardiac health and disease. However, although much information has been gleaned from
Chen-Izu, Ye, Jaradeh, Mark, Jian, Zhong, Reddy, Gopireddy Raghavender, Shi, Qian, Wang, Ying, West, Toni M, Xiang, Yang K   +7 more
core  

Pharmacological inhibition of PKCθ counteracts muscle disease in a mouse model of duchenne muscular dystrophy [PDF]

, 2017
Inflammation plays a considerable role in the progression of Duchenne Muscular Dystrophy (DMD), a severe muscle disease caused by a mutation in the dystrophin gene. We previously showed that genetic ablation of Protein Kinase C θ (PKCθ) in mdx, the mouse
Benedetti, Anna, Bouche', Marina, Fiore, PIERA FILOMENA, LOZANOSKA OCHSER, Biliana, Madaro, Luca, Marrocco, Valeria, Musaro', Antonio, Pisu, Simona, Rizzuto, Emanuele   +8 more
core   +2 more sources