Results 171 to 180 of about 6,808 (263)

Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression. [PDF]

Eur Heart J
Heimerl M, Erschow S, Müller-Olling M, Manstein DJ, Decher N, Kauferstein S, Jenewein T, Pich A, Ricke-Hoch M, Hilfiker-Kleiner D.   +9 more
europepmc   +1 more source

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin‐Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes reactive oxygen species production and iron ...
Ashley J. Smuder, Vivian Doerr, Cesar E. Jacintho Moritz, Jie Li, Branden L. Nguyen   +4 more
wiley   +1 more source

MYH6-Cre Insertion Accelerates Cardiac Phenotype in Dystrophic D2-mdx Mice. [PDF]

FASEB J
Hawkins IK, Phi T, Mitchell J, Corwin F, Mauro AG, Salloum FN, Raucci FJ.   +6 more
europepmc   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Danicamtiv increases cardiac mechanical efficiency. [PDF]

J Physiol
Meehan T, Pham T, Tran K, Taberner AJ, Han JC.   +4 more
europepmc   +1 more source

Direct AMPK Activation Confers Mutation‐Independent Therapeutic Benefit in Duchenne Muscular Dystrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is a severe, life‐limiting neuromuscular disorder (NMD) characterized by progressive muscle wasting and mitochondrial dysfunction. Although gene therapies offer promise, even those already approved by regulatory agencies, their use remains constrained by mutation specificity, delivery challenges and
Sean Y. Ng, Andrew I. Mikhail, Stephanie R. Mattina, Magda A. Lesinski, Irena A. Rebalka, Sophie I. Hamstra, Donald Xhuti, Val A. Fajardo, Mark A. Tarnopolsky, Joshua P. Nederveen, Gregory R. Steinberg, Thomas J. Hawke, Vladimir Ljubicic   +12 more
wiley   +1 more source

Pharmacological Inhibition of β Myosin II Disrupts Sarcomere Assembly in Human iPSC-Derived Cardiac Myocytes. [PDF]

Cytoskeleton (Hoboken)
Hayes JB, Burnette DT.
europepmc   +1 more source

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Comparative analysis of multiple cell culture models. The 3D microfluidic organ‐on‐a‐chip, which is superior to the existing models in multiple aspects, can be more conducive to new studies and discoveries related to human beings. Created with BioRender (www.biorender.com).
Xuxia Cao, Congmin Xia, Caifeng Li, Shiwen Deng, Junxian Cao, Hongjun Yang, Shaoping Wang, Peng Chen   +7 more
wiley   +1 more source

A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif. [PDF]

Proc Natl Acad Sci U S A
Goluguri RR, Guhathakurta P, Nandwani N, Dawood A, Yokota S, Roopnarine O, Thomas DD, Ruppel KM, Spudich JA.   +8 more
europepmc   +1 more source

Characterization of Cardiac Myosin from the Dog

Journal of Biological Chemistry, 1964
H, MUELLER, J, FRANZEN, R V, RICE, R E, OLSON   +3 more
openaire   +2 more sources