Multicentre retrospective propensity‐score‐matched cohort study (n = 286; 3 centres, Pakistan; 2015‐2023) comparing electrophysiological substrate and 12‐month ablation outcomes in patients with atrial fibrillation and hypertrophic cardiomyopathy (HCM‐AF, red) versus lone atrial fibrillation (Lone AF, green; 1:1 PSM on 14 covariates).
Umair Abrar +7 more
wiley +1 more source
Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle. [PDF]
Hill C +7 more
europepmc +1 more source
Electroconductive Soft Microcarriers for Suspension Culture of Skeletal Muscle Cells
ABSTRACT The advancement of conductive biomaterials is essential for engineering electrically responsive tissues, such as skeletal muscle, cardiac, and neural tissues. Traditional hydrogel‐based microcarriers (MCs) lack inherent conductivity, limiting their potential for cell signaling and differentiation. In this study, we present a soft conductive MC
Aynaz Saket Balgouri +6 more
wiley +1 more source
Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression. [PDF]
Heimerl M +9 more
europepmc +1 more source
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
MYH6-Cre Insertion Accelerates Cardiac Phenotype in Dystrophic D2-mdx Mice. [PDF]
Hawkins IK +6 more
europepmc +1 more source
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source
Pharmacological Inhibition of β Myosin II Disrupts Sarcomere Assembly in Human iPSC-Derived Cardiac Myocytes. [PDF]
Hayes JB, Burnette DT.
europepmc +1 more source
Inflammation, Immunity, and Cardiovascular Diseases
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
Single-Molecule Investigation of Load-Dependent Actomyosin Dissociation Kinetics for Cardiac and Slow Skeletal Myosin. [PDF]
Wang T +3 more
europepmc +1 more source

