Results 171 to 180 of about 6,676 (255)

SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley   +1 more source

Danicamtiv reduces myosin's working stroke but activates the thin filament by accelerating actomyosin attachment. [PDF]

Proc Natl Acad Sci U S A
Scott B, Greenberg L, Squarci C, Campbell KS, Greenberg MJ.   +4 more
europepmc   +1 more source

Bed rest decreases resting skeletal muscle O2 uptake and resting energy expenditure in young and elderly subjects

Experimental Physiology, Volume 111, Issue 5, Page 2599-2612, 1 May 2026.
Abstract A decrease in resting muscle O2 uptake (V̇O2m${\dot V_{{{\mathrm{O}}_2}{\mathrm{m}}}}$) described during bed rest (BR) could determine a decreased whole‐body resting energy expenditure (REE), potentially useful during prolonged spaceflights. Two groups of recreationally active men (young [Y], n = 8, age 23 ± 5 years; elderly [E], n = 10, age ...
Giovanni Baldassarre, Simone Porcelli, Lucrezia Zuccarelli, Lorenza Brocca, Noemi Arboit, Laura Gobbo, Michele Lacerenza, Alessio Marciano, Chiara Motto, Giulia Sanguin, Mladen Gasparini, Boštjan Šimunič, Rado Pišot, Marco Narici, Bruno Grassi   +14 more
wiley   +1 more source

Muscle contraction mechanism [PDF]

, 2017
Koch, D., Schaub, M.C.
core  

Myosinopathies: pathology and mechanisms [PDF]

core   +1 more source

Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. [PDF]

Am J Physiol Heart Circ Physiol
Vaughan OR, Goodspeed A, Sucharov CC, Powell TL, Jansson T.   +4 more
europepmc   +1 more source

Danicamtiv increases cardiac mechanical efficiency. [PDF]

J Physiol
Meehan T, Pham T, Tran K, Taberner AJ, Han JC.   +4 more
europepmc   +1 more source

Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle. [PDF]

Physiol Rep
Kuehn MN, Engels NM, Nissen DL, Freundt JK, Ma W, Harris SP, Irving TC, Linke WA, Hessel AL.   +8 more
europepmc   +1 more source

Coupling between the lever arm and active site via an N-terminal extension tunes force sensitivity in the myosin-1 family. [PDF]

Proc Natl Acad Sci U S A
Rathbone HW, Houdusse A.
europepmc   +1 more source

Characterization of Cardiac Myosin from the Dog

Journal of Biological Chemistry, 1964
H, MUELLER, J, FRANZEN, R V, RICE, R E, OLSON   +3 more
openaire   +2 more sources