Results 161 to 170 of about 4,202 (274)

A case of hypertrophic cardiomyopathy presenting with high-degree atrioventricular block. [PDF]

Medicine (Baltimore)
Gu Y, Chen F, Zhang C.
europepmc   +1 more source

Myosin Post‐Translational Modifications Associated With Critical Illness Myopathy

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Background Critical illness myopathy is a common and devastating consequence of critical care, causing dramatic loss of muscle mass and function in intensive care unit patients. Functional deficits often exceed the loss in muscle mass and myosin content.
Fernando Ribeiro, Bruno Di Geronimo, Nicola Cacciani, Anna Widgren, Yvette Hedström, Anselmo S. Moriscot, Peter M. Kasson, Shina C. L. Kamerlin, Jonas Bergquist, Lars Larsson   +9 more
wiley   +1 more source

Cryo-EM reveals how cardiomyopathy therapeutic drugs modulate the myosin motors of the heart. [PDF]

Sci Adv
Somavarapu AK, Ge J, Yengo CM, Craig R, Padron R.   +4 more
europepmc   +1 more source

Molecular weight studies of canine cardiac myosins

, 1974
Wikman-Coffelt, Joan, Dean T. Mason, Alan Smith, Mason, Dean T., Smith, Alan, Joan Wikman-Coffelt   +5 more
core   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Danicamtiv reduces myosin's working stroke but activates the thin filament by accelerating actomyosin attachment. [PDF]

Proc Natl Acad Sci U S A
Scott B, Greenberg L, Squarci C, Campbell KS, Greenberg MJ.   +4 more
europepmc   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Transcriptomic Remodeling of Pulmonary Vein Sleeves Suggests a Role in Atrial Arrhythmogenesis in Thoroughbred Horses. [PDF]

Ann N Y Acad Sci
Arevalo-Turrubiarte M, Edling CE, Moller-Levet C, Forbes B, Kemp V, Weir J, Marr C, Lewis R, Jeevaratnam K.   +8 more
europepmc   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Force-Induced Ankle Opening Reveals Mechanical Stabilization of the Ankle of Human β-Cardiac Myosin. [PDF]

ACS Nano
Deopa SPS, Bjorkman KK, Edwards DT, LeBlanc MA, Buvoli M, Oakes SH, Dzuba B, Karabina A, Leinwand LA, Perkins TT.   +9 more
europepmc   +1 more source