CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.ABSTRACT In the phase 3 study SEQUOIA‐HCM (NCT05186818), aficamten, a next‐in‐class cardiac myosin inhibitor, was safe and efficacious in participants with obstructive hypertrophic cardiomyopathy (oHCM). Using pharmacokinetics/pharmacodynamics (PKPD) modeling, we quantified the relationship between aficamten exposure and cardiodynamic measures of ...
Justin D. Lutz +5 more
wiley +1 more source
Mechanisms of mitral valve development and disease. [PDF]
Front Cardiovasc MedWang E, Zhou B.
europepmc +1 more source
UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia
Aging Cell, Volume 25, Issue 5, May 2026.Aging reduces Unc45b expression in fast‐twitch muscle, concomitant with reduction in muscle contractile capacity and muscle mass in mice. Unc45b deficiency initially reduces depolarization‐induced force, followed by a decline in fast‐twitch muscle mass in adult mice.
Taiga Mishima +17 more
wiley +1 more source
Bleeding Disorders in Children With Genetic Diseases: A Narrative Review
Acta Paediatrica, Volume 115, Issue 5, Page 1015-1024, May 2026.ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol +6 more
wiley +1 more source
A case of hypertrophic cardiomyopathy presenting with high-degree atrioventricular block. [PDF]
Medicine (Baltimore)Gu Y, Chen F, Zhang C.
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: Application to the study of human β-cardiac myosin. [PDF]
J Biol ChemBarua B +4 more
europepmc +1 more source
T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter +3 more
wiley +1 more source
Transcriptomic Remodeling of Pulmonary Vein Sleeves Suggests a Role in Atrial Arrhythmogenesis in Thoroughbred Horses. [PDF]
Ann N Y Acad SciArevalo-Turrubiarte M +8 more
europepmc +1 more source
Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives [PDF]
, 2016 core +1 more source