Results 151 to 160 of about 6,676 (255)

Deubiquitinase YOD1 Inhibition Suppresses DEX‐ and Denervation‐Induced Muscle Atrophy Through MAFbx Destabilization

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains unclear. This study aims to identify a deubiquitinase (DUB)
Jongbeom Chae, Seon Min Woo, Seung Un Seo, Simmyung Yook, Hyo Je Cho, Jung Yeol Lee, Kyoung jin Min, Junhyeon Park, Dongryeol Ryu, Taeg Kyu Kwon   +9 more
wiley   +1 more source

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically. [PDF]

Nat Commun
Nandwani N, Bhowmik D, Glaser C, Childers MC, Goluguri RR, Dawood A, Regnier M, Houdusse A, Spudich JA, Ruppel KM.   +9 more
europepmc   +1 more source

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age‐related deterioration.
So Jeong Park, Ji Yeon Baek, Shibo Wei, Jin Young Lee, Yuna Lee, Sang‐Hoon Lee, Il‐Young Jang, Hyuk Sakong, Hyun Ju Yoo, Hee‐Won Jung, Eunju Lee, Su Jung Kim, Yunju Jo, Kyunggon Kim, Dongryeol Ryu, Beom‐Jun Kim   +15 more
wiley   +1 more source

Cryo-EM structure of shutdown human nonmuscle myosin 2A. [PDF]

Sci Adv
Casas-Mao D, Carrington G, Peckham M.
europepmc   +2 more sources

Relationship Between Filament‐Polymerizing Muscle Myosin and Droplets Generated by Liquid–Liquid Phase Separation

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
A droplet formed by liquid–liquid phase separation (LLPS) that has deformed and even developed a protrusion due to the inclusion of meshwork structures formed by the assembly of myosin filaments. So far, such droplet deformation has not been observed and was not possible with either DNA or actin filaments.
Tatsuyuki Waizumi, Mahito Kikumoto, Tomoharu Matsumoto, Kingo Takiguchi   +3 more
wiley   +1 more source

Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus. [PDF]

Cardiovasc Diabetol
Degezelle MM, Chaami C, Lewis CTA, Zhang C, Hessel AL, Rainer PP, Kirk JA, Stokke MK, Seaborne RAE, Ochala J.   +9 more
europepmc   +1 more source

Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
A tunable composite contractile assembly (CCA) is developed that can permit or resist contraction without changing cell‐adhesion and density, unlike collagen whose inherent coupling of these ECM cues limits its use as a platform in contractility studies.
Karen L. Xu, Yuqi Zhang, Alysse DeFoe, Georgios Kotsaris, Brendan Stoeckl, Matthew D. Davidson, Jason A. Burdick, Robert L. Mauck   +7 more
wiley   +1 more source

Editorial: Hypertrophic Cardiomyopathy and Precision Medicine in Cardiovascular Disease. [PDF]

Med Sci Monit
Parums DV.
europepmc   +1 more source

Post Activation Potentiation Is Greater in Human Triceps Brachii Versus Triceps Surae Muscles

Muscle &Nerve, Volume 73, Issue 5, Page 815-821, May 2026.
ABSTRACT Introduction/Aims Voluntary muscle contractions result in a temporary increase in twitch force, a phenomenon termed post activation potentiation (PAP). In rodents and other species, PAP is observed predominantly or exclusively in fast twitch muscles. However, it has been suggested that in humans, PAP occurs more or less independently of muscle
William S. Zoughaib, Madison J. Fry, Ahaan Singhal, Richard L. Hoffman, Andrew R. Coggan   +4 more
wiley   +1 more source

Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states. [PDF]

J Biol Chem
Cail RC, Báez-Cruz FA, Winkelmann DA, Goldman YE, Ostap EM.   +4 more
europepmc   +1 more source