Results 131 to 140 of about 4,049 (222)

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: Application to the study of human β-cardiac myosin. [PDF]

J Biol Chem
Barua B, Cail RC, Goldman YE, Ostap EM, Winkelmann DA.   +4 more
europepmc   +1 more source

Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha‐Fatty‐Acid Amide Hydrolase 1 Signaling Pathway

MedComm, Volume 7, Issue 8, August 2026.
1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa, Alba Cabaleiro, Borja López‐Picallo, Natalia da Silva Lima, Cristina Riobello, Carmen Pena, Jose Iglesias‐Moure, Ana Senra, Maria Luz Martínez‐Chantar, Anabel Fernandez‐Iglesias, Jordi Gracia‐Sancho, Susana Bravo, Carlos Dieguez, Marta Varela‐Rey, Vincent Prevot, Markus Schwaninger, Miguel López, Rubén Nogueiras   +17 more
wiley   +1 more source

A case of hypertrophic cardiomyopathy presenting with high-degree atrioventricular block. [PDF]

Medicine (Baltimore)
Gu Y, Chen F, Zhang C.
europepmc   +1 more source

Targeting of Pentraxin 3 Alleviated Cardiac Hypertrophy in Mice Induced by Angiotensin II

Clinical and Experimental Pharmacology and Physiology, Volume 53, Issue 8, August 2026.
ABSTRACT Pentraxin 3 (PTX3) responds rapidly to inflammatory signals. This study investigated the functional involvement of PTX3 in angiotensin II (Ang II)‐mediated cardiac hypertrophy pathogenesis, with particular focus on its potential regulation through inflammatory pathways and oxidative stress mechanisms.
Qiming Tan, Xiaoxuan Gong, Tian Wu, Chen Li, Kun Liu, Daorong Hou   +5 more
wiley   +1 more source

Danicamtiv reduces myosin's working stroke but activates the thin filament by accelerating actomyosin attachment. [PDF]

Proc Natl Acad Sci U S A
Scott B, Greenberg L, Squarci C, Campbell KS, Greenberg MJ.   +4 more
europepmc   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, Volume 183, Issue 16, Page 5120-5147, August 2026.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Cryo-EM reveals how cardiomyopathy therapeutic drugs modulate the myosin motors of the heart. [PDF]

Sci Adv
Somavarapu AK, Ge J, Yengo CM, Craig R, Padron R.   +4 more
europepmc   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Force-Induced Ankle Opening Reveals Mechanical Stabilization of the Ankle of Human β-Cardiac Myosin. [PDF]

ACS Nano
Deopa SPS, Bjorkman KK, Edwards DT, LeBlanc MA, Buvoli M, Oakes SH, Dzuba B, Karabina A, Leinwand LA, Perkins TT.   +9 more
europepmc   +1 more source