Results 111 to 120 of about 4,049 (222)

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically. [PDF]

Nat Commun
Nandwani N, Bhowmik D, Glaser C, Childers MC, Goluguri RR, Dawood A, Regnier M, Houdusse A, Spudich JA, Ruppel KM.   +9 more
europepmc   +1 more source

Cardiac Myosin Heavy Chains

Cardiology and Angiology: An International Journal, 2019
Muhanad S. Abdelwahab, Mukhallad Am. Mohamemed, Abdelwahab Hassan Mohamed, Mansour Abdelgader Bellal, Mazin S. Abdalla Mohamed   +4 more
openaire   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through In Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, Volume 13, Issue 45, 13 August 2026.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Evidence‐Based Nursing Management During Mavacamten Therapy in an 89‐Year‐Old Patient With Symptomatic Hypertrophic Obstructive Cardiomyopathy: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT In older patients receiving mavacamten, a reduction in NT‐proBNP levels may coexist with persistent severe LVOTO. Nurses should interpret this biomarker–echocardiography discordance as a safety signal and maintain structured cardiovascular surveillance rather than assuming treatment success based solely on biomarker improvement.
Feifei Wang
wiley   +1 more source

Pulmonary parenchyma becomes a self-organized dissipative structure in lung cancers and pulmonary inflammatory diseases. [PDF]

Physiol Rep
Lecarpentier Y, Morini A, Tremblay B, Locher C, Krokidis X, Claes V, Schussler O, Locher C.   +7 more
europepmc   +1 more source

Polarized Light Microscopy for Quantitative Assessment of Sarcomere‐Scale Structural Order in Cardiac Tissue

Journal of Biophotonics, Volume 19, Issue 8, August 2026.
Impact of cardiac and respiratory arrest on cardiac muscle tissue. Wistar rats were injected (on the left) either with cisatracurium to induce a respiratory arrest or lidocaine to induce a cardiac arrest (in the middle). Further, the pathophysiological changes developed and were assessed with linear polarization microscopy at 600–3000 nm wavelength ...
Gennadii Piavchenko, Artem Venediktov, Zoya Shamitko, Karina Urazova, Mariia Obelchakova, Evelina Khabarova, Anton Ershov, Natalia Kartashkina, Viktoria Grikh, Valerii Smirnov, Galina Ramenskaya, Alexander Yatskovskiy, Igor Meglinski   +12 more
wiley   +1 more source

Multiscale adaptations underlie bite force variation in rodents. [PDF]

Commun Biol
Brocklehurst RJ, LaFave N, Reder BP, Moore JR, Konow N.   +4 more
europepmc   +1 more source

Dnajb5 From Antarctic Fish Reveals a Redox‐Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho, Min‐Kyung Choi, Mi‐Ock Baek, Hyeon‐Hee Son, Binh Thanh Nguyen, Min‐Jung Kang, Il‐Chan Kim, Jin‐Hyoung Kim, Mee‐Sup Yoon   +8 more
wiley   +1 more source

Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states. [PDF]

J Biol Chem
Cail RC, Báez-Cruz FA, Winkelmann DA, Goldman YE, Ostap EM.   +4 more
europepmc   +1 more source