Results 141 to 150 of about 6,676 (255)

Prenylcysteine Oxidase 1 Deficiency Protects the Cardiac Muscle Cell Line HL-1 Against Ischaemic/Hypoxic Stress. [PDF]

FASEB J
Ischaemic/hypoxic stress leads to heart remodeling and dysfunction. PCYOX1 promotes cardiomyocyte survival during injury, reducing the generation of reactive oxygen species. PCYOX1 deficiency regulates key proteins to preserve cardiomyocyte structure and function such as creatine kinase.
Banfi C, Brocca L, Bascucci A, Papaianni GG, Mallia A, Eligini S.   +5 more
europepmc   +2 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Novel cardiac myosin inhibitor for hypertrophic cardiomyopathy

Journal of General Physiology
New RLC-1 small-molecule inhibits actomyosin interactions, reduces contractile force, and speeds up myosin cross-bridge kinetics.
openaire   +2 more sources

Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend We recorded time‐resolved small‐angle X‐ray diffraction patterns from rat soleus muscles during fixed‐end twitch and tetanic contractions to investigate the structural basis of the lower fixed‐end force generated by these muscles compared with fast muscles, such as the mouse extensor digitorum longus (EDL).
Cameron Hill, Michaeljohn Kalakoutis, Alice Arcidiacono, Yanhong Wang, Emma Smith, Elisabetta Brunello, Luca Fusi, Malcolm Irving   +7 more
wiley   +1 more source

A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment. [PDF]

Proc Natl Acad Sci U S A
Cail RC, Barua B, Báez-Cruz FA, Winkelmann DA, Goldman YE, Ostap EM.   +5 more
europepmc   +1 more source

Direct measurement of mavacamten and deoxyATP perturbation of the SRX/DRX ratio in porcine cardiac myofibrils using a simple, accessible and multiplexed approach. [PDF]

J Muscle Res Cell Motil
Pilagov M, Naim A, Campbell KS, Kampourakis T, Geeves MA, Kad NM.   +5 more
europepmc   +1 more source

Bright Ferritin for Non‐Invasive MRI Monitoring of the Fate of Transplanted hPSC‐Cardiomyocytes in the Infarcted Rat Heart

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 323-338, July 2026.
ABSTRACT Purpose To demonstrate that a recently reported bright ferritin magnetic resonance imaging (MRI) platform can track transplanted human pluripotent stem cell (hPSC)‐derived cardiomyocytes (hPSC‐CMs) longitudinally and on‐demand in the rat heart.
Keyu Zhuang, Faisal J. Alibhai, Beiping Qiang, Rocco Romagnuolo, Kyle D. W. Vollett, Bradley K. C. Freeman, M. Juliana Gomez‐Garcia, Tamilla Sadikov Valdman, Tameshwar Ganesh, Yu‐Qing Zhou, Hai‐Ying Mary Cheng, Michael A. Laflamme, Hai‐Ling Margaret Cheng   +12 more
wiley   +1 more source

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity. [PDF]

J Gen Physiol
Pilagov M, Steczina S, Naim A, Regnier M, Geeves MA, Kad NM.   +5 more
europepmc   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Resolving zone-specific regulation of cardiac myosin. [PDF]

J Gen Physiol
Nelson SR.
europepmc   +1 more source