Results 131 to 140 of about 157,414 (301)

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source

Modeling of multifunctional porous tissue scaffolds with continuous deposition path plan [PDF]

, 2012
A novel modeling technique for porous tissue scaffolds with targeting the functionally gradient variational porosity with continuous material deposition planning has been proposed.
Khoda, AKM B., Koc, Bahattin, Koç, Bahattin, Ozbolat, Ibrahim T., Özbolat, İbrahim T.   +4 more
core   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]

, 2014
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y, Chooljian, Marc S, Conboy, Irina M, Cousin, Wendy, Elabd, Christian, Jiang, Kevin P, Kung, Sunny, Li, Ju, Upadhyayula, Pavan   +8 more
core   +1 more source

Tunable Bioresorbable Scaffolds With Marine Sulfated Polysaccharides for Small‐Caliber Vascular Grafts: A Multi‐Layered Strategy Combining Electrospinning and 4‐Axis Printing

Advanced Healthcare Materials, EarlyView.
A multilayered small‐caliber vascular scaffold combining electrospinning and 4‐axis printing is developed and biofunctionalized with marine sulfated polysaccharides from Holothuria tubulosa. The resulting construct exhibits enhanced hemocompatibility, tunable mechanical properties, and supports endothelial and smooth muscle cell adhesion and ...
Gabriele Obino, Alberto Sensini, Tim ten Brink, Gabriele Nieddu, Tristan Bodet, Giovanni Andrea Deiana, Martijn van Griensven, Marilena Formato, Antonio J. Lepedda, Lorenzo Moroni   +9 more
wiley   +1 more source

EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization

Journal of Cachexia, Sarcopenia and Muscle
Background Muscle atrophy has a poor prognosis, caused by various factors. Identifying a shared treatment target could address an unmet clinical need.
Qian Li, Xiaohang Yin, Wensi Wan, Yi Zhou, Siqi Wang, Yuwei Yan, Jingying Chen, Xinyi Ren, Junli Gao, Yuying Chen, Yanan Zhang, Caiyue Cui, Emeli Chatterjee, Guoping Li, Ming Wu, Yan Zhang, Dongchao Lu, Tingting Yang, Yongjun Zheng, Jin Li   +19 more
doaj   +1 more source

Covering and Re-Covering the Heart: Development and Regeneration of the Epicardium

Journal of Cardiovascular Development and Disease, 2018
The epicardium, a mesothelial layer that envelops vertebrate hearts, has become a therapeutic target in cardiac repair strategies because of its vital role in heart development and cardiac injury response.
Yingxi Cao, Jingli Cao
doaj   +1 more source

Ranolazine Attenuates Trastuzumab-Induced Heart Dysfunction by Modulating ROS Production [PDF]

, 2018
The ErbB2 blocker trastuzumab improves survival in oncologic patients, but can cause cardiotoxicity. The late Na+ current inhibitor ranolazine has been shown to counter experimental HF, including doxorubicin cardiotoxicity (a condition characterized by ...
Carlo G. Tocchetti, Carlo Maurea, Carmela Coppola, Chiara D'Avino, Chiara D'Avino, Claudia De Lorenzo, Claudia De Lorenzo, Claudio Arra, Danilo Fiore, Domenica Rea, Fabio Di Lisa, Gennaro Riccio, Gerolama Condorelli, Giovanna Piscopo, Michele Russo, Nicola Maurea, Salvatore Antonucci   +16 more
core   +3 more sources

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Wharton’s jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: a preliminary report [PDF]

, 2013
The therapeutic effect of mesenchymal stromal cells (MSCs) following myocardial infarction (MI) is small. This may be due to differences in cellular sources and donor age, route of administration, in vitro cellular manipulations and the short time course
Borgarelli, Michele, Hageman, Karen S., Lutjemeier, Barbara, López, Yelica, Musch, Timothy I., Seshareddy, Kiran, Trevino, Elizabeth M., Weiss, Mark L.   +7 more
core   +2 more sources