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Animal Models to Study Cardiac Regeneration [PDF]
Nature Reviews CardiologyPermanent fibrosis and chronic deterioration of heart function in patients after myocardial infarction present a major health-care burden worldwide. In contrast to the restricted potential for cellular and functional regeneration of the adult mammalian ...
Michael Weinberger, Paul R Riley
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microRNA and Cardiac Regeneration
2015Heart diseases are a very common health problem in developed as well as developing countries. In particular, ischemic heart disease and heart failure represent a plague for the patients and for the society. Loss of cardiac tissue after myocardial infarction or dysfunctioning tissue in nonischemic cardiomyopathies may result in cardiac failure.
GNECCHI, MASSIMILIANO +2 more
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An Emerging Consensus on Cardiac Regeneration [PDF]
Nature Medicine, 2014 Cardiac regeneration is a rapidly evolving and controversial field of research. The identification some 12 years ago of progenitor cells that reside within the heart spurred enthusiasm for cell-based regenerative therapies. However, recent evidence has called into question both the presence of a biologically important stem cell population in the heart ...
Jop H van Berlo +2 more
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CARDIAC REGENERATION: Repopulating the Heart
Annual Review of Physiology, 2006▪ Abstract Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is, induction of regenerative cardiac growth), cardiac disease potentially can be reversed, provided that the newly formed myocytes structurally and functionally integrate in the ...
Michael, Rubart, Loren J, Field
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YAP at the Heart of Cardiac Regeneration
Nature Reviews CardiologyGhulam Mehdi Dar
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microRNAs in cardiac development and regeneration
Clinical Science, 2013Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent studies have established critical functions for these tiny RNAs in almost ...
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The Evolving Cardiac Lymphatic Vasculature in Development, Repair and Regeneration
Nature Reviews Cardiology, 2021Konstantinos Klaourakis +2 more
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ERBB2–YAP Crosstalk Mediates Cardiac Regeneration in Mice
Nature Reviews Cardiology, 2021Irene Fernández-Ruiz
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Hallmarks of Cardiac Regeneration
Nature Reviews Cardiology, 2018Alessandro Bertero, Charles Murry
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