Results 1 to 10 of about 801,889 (178)

cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish [PDF]

Journal of Cardiovascular Development and Disease
Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng, Jingyi Ju, Wenping Huang, Zongyi Duan, Yanchao Han   +4 more
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Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice [PDF]

Frontiers in Cell and Developmental Biology, 2019
Cardiomyocyte proliferation accounts for the increase of cardiac muscle during fetal mammalian heart development. Shortly after birth, cardiomyocyte transits from hyperplasia to hypertrophic growth.
Tongtong Cao, Tongtong Cao, Daniela Liccardo, Ryan LaCanna, Xiaoying Zhang, Rong Lu, Brian N. Finck, Tani Leigh, Xiongwen Chen, Konstantinos Drosatos, Ying Tian   +10 more
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Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation [PDF]

Journal of Cardiovascular Development and Disease
The limited capacity for cardiomyocyte proliferation in the adult human heart restricts its ability to recover from injury. Building on discoveries in regenerative model systems, such as zebrafish and neonatal mice, reactivation of a latent potential for
Richard D. McLane, Abhay Cheruku, Ashley B. Williams, Ravi Karra   +3 more
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Foxk1 and Foxk2 promote cardiomyocyte proliferation and heart regeneration [PDF]

Nature Communications
Promoting endogenous cardiomyocyte proliferation is a promising strategy for cardiac repair. Identifying key factors that regulate cardiomyocyte proliferation can advance the development of novel therapies for heart regeneration.
Dongcheng Cai, Chungeng Liu, Haotong Li, Chiyin Wang, Lina Bai, Jie Feng, Miaoqing Hu, Hao Wang, Shen Song, Yifan Xie, Ziwei Chen, Jiajun Zhong, Hong Lian, Zhiwei Yang, Yuhui Zhang, Yu Nie   +15 more
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HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming [PDF]

Advanced Science
The neonatal heart possesses the unique ability to regenerate post‐injury. Underlying related mechanisms and reactivation of this process are crucial for regeneration medicine.
Liu‐Hua Zhou, Ling‐Feng Gu, Yi‐Xi Chen, Peng Jing, Tong‐Tong Yang, Ye He, Yu‐Lin Bao, Xiang‐Zheng Zhang, Chong Du, Si‐Bo Wang, Tian‐Kai Shan, Jia‐Yi Chen, Hao Wang, Qi‐Ming Wang, Li‐Ping Xie, Yang Zhao, Yong Ji, Lian‐Sheng Wang   +17 more
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Cardiomyocyte proliferation and regeneration in congenital heart disease [PDF]

Pediatric Discovery
Despite advances in prenatal screening and a notable decrease in mortality rates, congenital heart disease (CHD) remains the most prevalent congenital disorder in newborns globally.
Jialiang Liang, Xingyu He, Yigang Wang
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Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration [PDF]

Nature Communications
Heart injury has been characterized by the irreversible loss of cardiomyocytes comprising the contractile tissues of the heart and thus strategies enabling adult cardiomyocyte proliferation are highly desired for treating various heart diseases. Here, we
Yi Xiao, Hao Zhang, Xu Liu, Pengfei Xu, Heng Du, Jiawan Wang, Jianghua Shen, Yujing Li, Yuhan Wang, Chuting He, Haiping Feng, Jingfang Liu, Yanan Zhou, Siqi Liu, Zeyu Gao, Jingyi Zang, Jinmiao Bi, Tie-Shan Tang, Qi Gu, Tuo Wei, Jun Wang, Moshi Song   +21 more
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Restoration of RBM22 overcomes the transcriptional and epigenetic barriers of cardiomyocyte proliferation for heart regeneration [PDF]

Nature Communications
Stimulating endogenous cardiomyocyte proliferation holds great therapeutic promise for cardiac repair, but how chromatin remodeling governs this process remains poorly understood.
Xuewen Duan, Yong Tan, Yunkai Zhang, Bo Wang, Sheng Zhang, Tong Li, Xingguang Liu, Zhenzhen Zhan   +7 more
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Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration [PDF]

Frontiers in Cell and Developmental Biology
The adult mammalian cardiomyocyte has a limited capacity for self-renewal, which leads to the irreversible heart dysfunction and poses a significant threat to myocardial infarction patients.
Kexiao Zheng, Yanglin Hao, Chenkun Xia, Shaoxian Cheng, Jizhang Yu, Zhang Chen, Yuan Li, Yuqing Niu, Shuan Ran, Song Wang, Weicong Ye, Zilong Luo, Xiaohan Li, Jiulu Zhao, Ran Li, Junjie Zong, Han Zhang, Longyong Lai, Pinyan Huang, Cheng Zhou, Jiahong Xia, Xi Zhang, Jie Wu   +22 more
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A meta-analysis and systematic review of myocardial infarction-induced cardiomyocyte proliferation in adult mouse heart [PDF]

BMC Medicine
Background The proliferation capacity of adult cardiomyocytes is very limited in the normal adult mammalian heart. Previous studies implied that cardiomyocyte proliferation increases after injury stimulation, but the result is controversial partly due to
Ya Liu, Lingyan Liu, Pengcheng Zhuang, Jiamin Zou, Xiaokang Chen, Hao Wu, Bingjun Lu, Wei Eric Wang   +7 more
doaj   +2 more sources