Results 1 to 10 of about 119,697 (212)

Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. [PDF]

PLoS ONE, 2013
Unlike its mammalian counterpart, the adult zebrafish heart is able to fully regenerate after severe injury. One of the most important events during the regeneration process is cardiomyocyte proliferation, which results in the replacement of lost ...
Ying Huang, Michael R Harrison, Arthela Osorio, Jieun Kim, Aaron Baugh, Cunming Duan, Henry M Sucov, Ching-Ling Lien   +7 more
doaj   +3 more sources

Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets [PDF]

MedComm
The substantial loss of cardiomyocytes resulting from myocardial infarction leads to pathological remodeling of the heart and the onset of heart failure.
Mingchuan Liu, Tingwei Peng, Rui Yu, Kexin Wang, Di Wang, Xiaojie Jia, Yan Zhang, Jianqiang Hu, Bingchao Qi, Yan Li   +9 more
doaj   +2 more sources

Absence of a prolonged macrophage and B cell response inhibits heart regeneration in the Mexican cavefish [PDF]

Nature Communications
A balanced immune response after cardiac injury is crucial to successful heart regeneration, but knowledge of what distinguishes a regenerative from a scarring response is still limited.
Esra Sengul, Helen G. Potts, Ryan D. Carter, William T. Stockdale, Laura Bevan, Maria Nozdrina, Jun Ying, Konstantinos Lekkos, Rita Alonaizan, Zhilian Hu, Abigail Goodship, Lucy O’Byrne, Madeleine E. Lemieux, Rebecca Richardson, Mathilda T. M. Mommersteeg   +14 more
doaj   +2 more sources

β-adrenergic receptor inhibits heart regeneration by downregulating Yap m6A modification [PDF]

Cell Death and Disease
Newborn mammals transiently maintain the heart regenerative capacity. β-adrenergic receptor (β-AR) is the most critical receptor in regulating cardiomyocyte behavior.
Kaihang Guan, Zijian Li
doaj   +2 more sources

Gene expression analysis of zebrafish heart regeneration.

PLoS Biology, 2006
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood.
Ching-Ling Lien, Michael Schebesta, Shinji Makino, Gerhard J Weber, Mark T Keating   +4 more
doaj   +2 more sources

FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice [PDF]

Nature Communications
The Forkhead box O3 (FoxO3) transcription factor is crucial to controlling heart growth in adulthood, but its exact role in cardiac repair and regeneration in postnatal mice remains unclear.
Jing-Bo Xia, Kun Liu, Xiao-Lin Lin, Hong-Ji Li, Jin-Hua Lin, Li Li, Chi-Qian Liang, Yan Cao, Na Wen, Zhao-Fu Liao, Hui Zhao, Kyu-Sang Park, Guo-Hua Song, Ze-Bing Ye, Dong-Qing Cai, Zhen-Yu Ju, Xu-Feng Qi   +16 more
doaj   +2 more sources

Interdependent changes of nuclear lamins, nuclear pore complexes, and ploidy regulate cellular regeneration and stress response in the heart

Nucleus, 2023
In adult mammals, many heart muscle cells (cardiomyocytes) are polyploid, do not proliferate (post-mitotic), and, consequently, cannot contribute to heart regeneration.
Yao Li, Alberto Bertozzi, Mellissa RW Mann, Bernhard Kühn   +3 more
doaj   +1 more source

Circulating virome and inflammatory proteome in patients with ST-elevation myocardial infarction and primary ventricular fibrillation

Scientific Reports, 2022
Primary ventricular fibrillation (PVF) is a life-threatening complication of ST-segment elevation myocardial infarction (STEMI). It is unclear what roles viral infection and/or systemic inflammation may play as underlying triggers of PVF, as a second hit
Teresa Oliveras, Elena Revuelta-López, Cosme García-García, Adriana Cserkóová, Ferran Rueda, Carlos Labata, Marc Ferrer, Santiago Montero, Nabil El-Ouaddi, Maria José Martínez, Santiago Roura, Carolina Gálvez-Montón, Antoni Bayes-Genis   +12 more
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Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

eLife, 2022
Cardiovascular disease is the leading cause of death worldwide due to the inability of adult heart to regenerate after injury. N6-methyladenosine (m6A) methylation catalyzed by the enzyme methyltransferase-like 3 (Mettl3) plays an important role in ...
Fu-Qing Jiang, Kun Liu, Jia-Xuan Chen, Yan Cao, Wu-Yun Chen, Wan-Ling Zhao, Guo-Hua Song, Chi-Qian Liang, Yi-Min Zhou, Huan-Lei Huang, Rui-Jin Huang, Hui Zhao, Kyu-Sang Park, Zhenyu Ju, Dongqing Cai, Xu-Feng Qi   +15 more
doaj   +1 more source

CUGBP1, a crucial factor for heart regeneration in mice

Cell Death and Disease, 2022
The mammalian heart is capable of achieving perfect regeneration following cardiac injury through sustained cardiomyocyte proliferation during the early period after birth.
Yang Liu, Huiwen Wang, Han Zhang, Jun Wang, Qun Liu, Youkun Bi, Shaole Song, Xinlong Qiao, Keqi Zhu, Yanyun Wu, Guangju Ji   +10 more
doaj   +1 more source