Results 21 to 30 of about 119,697 (212)
Cell Reports, 2019 Summary: The regeneration capacity of neonatal mouse heart is controversial. In addition, whether epicardial cells provide a progenitor pool for de novo heart regeneration is incompletely defined.
Weibin Cai +8 more
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eLife, 2020 Injury to the newborn mouse heart is efficiently regenerated, but this capacity is lost by one week after birth. We found that IGF2, an important mitogen in heart development, is required for neonatal heart regeneration.
Hua Shen +9 more
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The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2
Nature Communications, 2018 LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-
Philipp Neumann +11 more
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Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish
Cell Reports, 2019 Summary: During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to ...
Marcos Sande-Melón +12 more
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Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration
Frontiers in Cell and Developmental Biology, 2021 Unlike the hearts of mammals, the adult zebrafish heart regenerates after injury. Heart cryoinjury in zebrafish triggers the formation of a fibrotic scar that gradually degrades, leading to regeneration.
Dimitrios Grivas +7 more
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Heart Regeneration in the Mexican Cavefish
Cell Reports, 2018 Summary: Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachón cave-dwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart.
William T. Stockdale +11 more
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Molecular regulation of myocardial proliferation and regeneration
Cell Regeneration, 2021 Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart. Here, we review both the classical
Lixia Zheng +5 more
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BiomoleculesFoam cell formation is a hallmark of atherosclerosis, yet the cellular complexity within foam cells in human plaques remains unexplored. Here, we integrate published single-cell RNA-sequencing, spatial transcriptomic, and chromatin accessibility ...
Yunrui Lu +9 more
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MicroRNAs in Postischemic Vascular Repair
Cardiology Research and Practice, 2012 The term angiogenesis describes the growth of endothelial sprouts from preexisting postcapillary venules. More recently, this term has been used to generally indicate the growth and remodeling process of the primitive vascular network into a complex ...
Andrea Caporali, Costanza Emanueli
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Nature Communications, 2022 Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ...
Donghong Zhang +7 more
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