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Application of Hydrogels in Cardiac Regeneration [PDF]

Cardiology and Therapy, 2023
Myocardial infarction (MI) is a leading cause of death globally. Due to limited cardiac regeneration, infarcted myocardial tissue is gradually replaced by cardiac fibrosis, causing cardiac dysfunction, arrhythmia, aneurysm, free wall rupture, and sudden ...
Xuejing Yu
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Editorial: Cardiac regeneration [PDF]

Frontiers in Cardiovascular Medicine, 2023
Rajika Roy, Claudio de Lucia, Darukeshwara Joladarashi, Ajit Magadum   +3 more
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The Role of Hydrogel in Cardiac Repair and Regeneration for Myocardial Infarction: Recent Advances and Future Perspectives

Bioengineering, 2023
A myocardial infarction (MI) is the leading cause of morbidity and mortality, seriously threatens human health, and becomes a major health burden of our society.
Ping Li, Jiajia Hu, Jian Wang, Junjie Zhang, Lu Wang, Chengliang Zhang   +5 more
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ENGINEERED EXTRACELLULAR VESICLES AND NANOPARTICLES: PROMISING TOOLS FOR DISEASE TREATMENT [PDF]

Archives of the Balkan Medical Union, 2020
Living forever is a beautiful vision that human being has been pursuing. With the development of science and technology, an increasing number of approaches have been emerging for repairing and regenerating the damaged organs, such as cell therapy, gene ...
Hongyun WANG, Xinyue ZHU, Junjie XIAO
doaj   +1 more source

Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b

Journal of Sport and Health Science, 2022
Background: Exercise is beneficial for muscle atrophy. Peroxisome proliferator-activated receptor gamma (PPARγ) and microRNA-29b (miR-29b) have been reported to be responsible for angiotensinⅡ (AngⅡ)-induced muscle atrophy. However, it is unclear whether
Qi Liu, Liyang Chen, Xuchun Liang, Yuqing Cao, Xinyue Zhu, Siqi Wang, Jin Li, Juan Gao, Junjie Xiao   +8 more
doaj   +1 more source

Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway

Cell Death and Disease, 2022
The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to β-cell failure. Oxidative stress is an important risk factor for PSC activation.
Jitai Zhang, Juan Bai, Qian Zhou, Yuxin Hu, Qian Wang, Lanting Yang, Huamin Chen, Hui An, Chuanzan Zhou, Yongyu Wang, Xiufang Chen, Ming Li   +11 more
doaj   +1 more source

Antithymocyte Globulin Inhibits CD8⁺ T Cell Effector Functions via the Paracrine Induction of PDL-1 on Monocytes

Cells, 2023
Background: Antithymocyte globulins (ATG) are T cell-depleting antibodies used in solid organ transplantation for induction therapy in sensitized patients with a high risk of graft rejection.
Dragan Copic, Martin Direder, Katharina Klas, Daniel Bormann, Maria Laggner, Hendrik Jan Ankersmit, Michael Mildner   +6 more
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The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation

Nature Communications, 2021
Mechanisms triggering hypertrophic scar formation remain poorly understood. Here the authors perform scRNA-seq on mature human hypertrophic scars and developing scars in mice to identify the serine proteases dipeptidyl-peptidase 4 and urokinase as key ...
Vera Vorstandlechner, Maria Laggner, Dragan Copic, Katharina Klas, Martin Direder, Yiyan Chen, Bahar Golabi, Werner Haslik, Christine Radtke, Erwin Tschachler, Konrad Hötzenecker, Hendrik Jan Ankersmit, Michael Mildner   +12 more
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The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

Pharmaceutics, 2023
Hypertrophic scars can cause pain, movement restrictions, and reduction in the quality of life. Despite numerous options to treat hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood.
Vera Vorstandlechner, Dragan Copic, Katharina Klas, Martin Direder, Bahar Golabi, Christine Radtke, Hendrik J. Ankersmit, Michael Mildner   +7 more
doaj   +1 more source

Circulating microRNAs in Response to Exercise Training in Healthy Adults

Frontiers in Genetics, 2020
Circulating microRNAs (miRNAs, miRs) have great potential as cardiac biomarkers and they are also being explored for their roles in intercellular communication and gene expression regulation.
Qiulian Zhou, Qiulian Zhou, Chao Shi, Yicheng Lv, Chenglin Zhao, Zheng Jiao, Tianhui Wang   +6 more
doaj   +1 more source