Results 41 to 50 of about 1,204,541 (198)
Cardiac Fibroblasts and Myocardial Regeneration [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The billions of cardiomyocytes lost to acute myocardial infarction (MI) cannot be replaced by the limited regenerative capacity of adult mammalian hearts, and despite decades of research, there are still no clinically effective therapies for remuscularizing and restoring damaged myocardial tissue.
Wangping Chen +4 more
openaire +3 more sources
Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
npj Systems Biology and Applications, 2017 Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we generated
Oriol Iborra-Egea +6 more
doaj +1 more source
A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function
JACC: Basic to Translational Science, 2016 Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment.
Isaac Perea-Gil, MS +10 more
doaj +1 more source
Circulation Research, 2004 See related article, pages 911–921 Despite current pharmacological and whole organ transplantation strategies, advanced heart failure remains a common and deadly disease.1 Limited availability of donor organs for use in orthotopic heart transplantation has prompted examination of alternative therapeutic strategies directed toward patients with ...
Daniel J. Garry, Cindy M. Martin
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Circular RNAs: Promising Biomarkers for Human Diseases
EBioMedicine, 2018 Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have suggested that circRNAs play a crucial role in regulating gene expression by acting as ...
Zhongrong Zhang +2 more
doaj +1 more source
Bioengineering, 2023 A myocardial infarction (MI) is the leading cause of morbidity and mortality, seriously threatens human health, and becomes a major health burden of our society.
Ping Li +5 more
doaj +1 more source
Lessons learnt in the first year of an Australian pediatric cardio oncology clinic
Cardio-Oncology, 2023 Background Modern oncological therapies together with chemotherapy and radiotherapy have broadened the agents that can cause cardiac sequelae, which can manifest for pediatric oncology patients while on active treatment.
Claudia Toro +16 more
doaj +1 more source
Metabolic Regulation of Cardiac Regeneration
Frontiers in Cardiovascular Medicine, 2022 The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure.
Xuewen Duan +2 more
openaire +3 more sources
Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and Regeneration [PDF]
, 2018 The heart is a complex organ consisting of various cell types, each of which plays an important role in both physiological and pathophysiological conditions.
Virpi Talman +3 more
core +1 more source
, 2021 The neonatal mammalian heart exhibits a remarkable regenerative potential, which includes fibrotic scar resolution and the generation of new cardiomyocytes.
Adwiteeya Misra +5 more
core +1 more source