Results 61 to 70 of about 158,981 (293)
Metabolic Regulation of Cardiac Regeneration
Frontiers in Cardiovascular Medicine, 2022 The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure.
Xuewen Duan +2 more
openaire +3 more sources
Nature Communications, 2021 Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic ...
Lukas S. Tombor +23 more
doaj +1 more source
Non-coding RNAs in Cardiac Regeneration
Frontiers in Physiology, 2021 The adult heart has a limited capacity to replace or regenerate damaged cardiac tissue following severe myocardial injury. Thus, therapies facilitating the induction of cardiac regeneration holds great promise for the treatment of end-stage heart failure,
Ting Yuan, Jaya Krishnan
doaj +1 more source
microRNAs in cardiac regeneration and cardiovascular disease [PDF]
, 2013 microRNAs (miRNAs) are a class of small non-coding RNAs, which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes.
Huang, Zhan-Peng +2 more
core +1 more source
The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
core +4 more sources
MicroRNAs in heart and circulation during physical exercise
Journal of Sport and Health Science, 2018 Exercise training is beneficial to the cardiovascular system. MicroRNAs (miRNAs, miRs) are a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of eukaryotic gene expression.
Lijun Wang +3 more
doaj +1 more source
Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis
Scientific Reports, 2022 Left ventricular (LV) remodeling after myocardial infarction (MI) is promoted by an intense fibrotic response, which could be targeted by the anti-fibrotic drug pirfenidone.
Alberto Aimo +8 more
doaj +1 more source
Physiological conditions influencing regenerative potential of stem cells [PDF]
, 2016 Stem cells are being used in the treatment of cardivovascular diseases. Here, we review the physiologic and pathologic conditions that impact the regenerative potential of stem cells in the treatment of cardiovascular diseases which include the influence
Avitabile, Daniele +3 more
core +1 more source
World Journal of Cardiology, 2016 The loss of cardiomyocytes during injury and disease can result in heart failure and sudden death, while the adult heart has a limited capacity for endogenous regeneration and repair. Current stem cell-based regenerative medicine approaches modestly improve cardiomyocyte survival, but offer neglectable cardiomyogenesis.
Kamps, Jan A.A.M., Krenning, Guido
openaire +2 more sources
Nature Communications, 2022 The benefit of regular exercise on the heart has been well documented but the role of RNA m6A modification in exercise-induced cardiac remodelling remains largely unknown.
Lijun Wang +10 more
doaj +1 more source