Results 61 to 70 of about 87,451 (296)
Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and Regeneration [PDF]
, 2018 The heart is a complex organ consisting of various cell types, each of which plays an important role in both physiological and pathophysiological conditions.
Virpi Talman +3 more
core +1 more source
Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis
Scientific Reports, 2022 Left ventricular (LV) remodeling after myocardial infarction (MI) is promoted by an intense fibrotic response, which could be targeted by the anti-fibrotic drug pirfenidone.
Alberto Aimo +8 more
doaj +1 more source
Circulation: Cardiovascular Genetics, 2015 The ability of the heart to regenerate to a meaningful extent after injury has been demonstrated in animal models, such as zebrafish1; however, higher organisms seem to have lost this advantageous capacity, leading to cell loss and subsequent heart failure after insult. Recent studies found a narrow window of regenerative opportunity during the first 7
openaire +2 more sources
Mechanisms of Cardiac Repair and Regeneration [PDF]
Circulation Research, 2018 Cardiovascular regenerative therapies are pursued on both basic and translational levels. Although efficacy and value of cell therapy for myocardial regeneration can be debated, there is a consensus that profound deficits in mechanistic understanding limit advances, optimization, and implementation.
Broughton, Kathleen M +6 more
openaire +5 more sources
Cardiac regeneration therapy: connections to cardiac physiology [PDF]
, 2011 Without heart transplantation, a large number of patients with failing hearts worldwide face poor outcomes. By means of cardiomyocyte regeneration, cardiac regeneration therapy is emerging with great promise as a means for restoring loss of cardiac ...
Hiroaki Matsubara, Naofumi Takehara
core +1 more source
Influence of Discontinuation of Cardiac Rehabilitation in Elderly Outpatients Due to the COVID-19 Pandemic [PDF]
, 2022 Background: The coronavirus disease 2019 (COVID-19) pandemic has restricted people’s activities and necessitated the discontinuation of cardiac rehabilitation (CR) programs for outpatients. In our hospital, CR for outpatients had to be discontinued for 3
Suematsu, Yasunori +21 more
core +1 more source
Revascularization of chronic total occlusion coronary artery and cardiac regeneration
Frontiers in Cardiovascular Medicine, 2022 Coronary chronic total occlusion (CTO) contributes to the progression of heart failure in patients with ischemic cardiomyopathy. Randomized controlled trials demonstrated that percutaneous coronary intervention (PCI) for CTO significantly improves angina
Ruoxi Liao +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
miR-29b contributes to multiple types of muscle atrophy
Nature Communications, 2017 Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy ...
Jin Li +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source