Results 61 to 70 of about 1,204,541 (198)
Circulation: Cardiovascular Genetics, 2015 The ability of the heart to regenerate to a meaningful extent after injury has been demonstrated in animal models, such as zebrafish1; however, higher organisms seem to have lost this advantageous capacity, leading to cell loss and subsequent heart failure after insult. Recent studies found a narrow window of regenerative opportunity during the first 7
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Strategies for Cardiac Regeneration and Repair [PDF]
Science Translational Medicine, 2014 Regenerative medicine strategies that enhance heart repair are being pursued to face the growing heart disease epidemic.
Zhiqiang, Lin, William T, Pu
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Feasibility of allogeneic stem cells for heart regeneration
, 2014 Stem cell therapy for heart disease is currently one of the most exciting ideas in regenerative medicine, and allogeneic mesenchymal stem cells (MSCs) are emerging as a lead candidate for cell-based therapeutics.
Suncion, V.Y +7 more
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Stem Cells and Cardiac Regeneration [electronic resource] /
, 2016 This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF).
Madonna, Rosalinda.editor.edthttp://id.loc.gov/vocabulary/relators/edt +1 more
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miR-29b contributes to multiple types of muscle atrophy
Nature Communications, 2017 Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy ...
Jin Li +11 more
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Revealing Pathways of Cardiac Regeneration [PDF]
Circulation: Genomic and Precision Medicine, 2018 See Article by Adamowicz, Morgan, and Haubner et al Major cardiac injuries like a large myocardial infarction lead to systolic heart failure because of loss of cardiomyocytes. Unlike during embryonic development,1 adult mammalian cardiomyocytes have limited ability to proliferate and replenish the adult mammalian heart.
Vinícius, Bassaneze, Richard T, Lee
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Cardiac Anisotropy, Regeneration, and Rhythm [PDF]
Circulation Research, 2014 With great interest, we read the commentary of Anderson et al1 on the recent publication of Chong et al2 about the large-scale use of human embryonic stem cell–derived cardiomyocytes to regenerate infarcted, nonhuman primate myocardium. In their commentary, they focus on the development of ventricular tachyarrhythmias after injection of large numbers ...
Pijnappels, D.A. +3 more
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Mechanisms of Cardiac Repair and Regeneration [PDF]
Circulation Research, 2018 Cardiovascular regenerative therapies are pursued on both basic and translational levels. Although efficacy and value of cell therapy for myocardial regeneration can be debated, there is a consensus that profound deficits in mechanistic understanding limit advances, optimization, and implementation.
Broughton, Kathleen M +6 more
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F1000Research, 2014 The pursuit of targeting multiple pathways in the ischemic cascade of cerebral stroke is a promising treatment option. We examined the regenerative potential of conditioned medium derived from rat and human apoptotic mononuclear cells (MNC), rMNCapo sec ...
Patrick Altmann +9 more
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Mechanobiology of cardiac regeneration
Current Opinion in Genetics & DevelopmentHeart function is tightly coupled to mechanical forces acting on cardiac cells, which are converted into intracellular signals that regulate gene expression and cellular behavior. While dysregulation of these forces contributes to cardiovascular diseases, their potential to guide regeneration remains an open and exciting area of investigation ...
Tuba Majid, Elif Eroglu
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