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Cardiac regeneration therapy: connections to cardiac physiology
, 2011 Without heart transplantation, a large number of patients with failing hearts worldwide face poor outcomes. By means of cardiomyocyte regeneration, cardiac regeneration therapy is emerging with great promise as a means for restoring loss of cardiac ...
Hiroaki Matsubara, Naofumi Takehara
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, 2021 Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly regenerate injured hearts and are excellent models to study the mechanisms of heart regeneration. Recent studies have shown that enhancers are able to respond to injury
Xueyu Li +4 more
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Experimental Models for the Study of Hereditary Cornification Defects
Biomedicines, 2021 Ichthyoses comprise a broad spectrum of keratinization disorders due to hereditary defects of cornification. Until now, mutations in more than 50 genes, mostly coding for structural proteins involved in epidermal barrier formation, have been identified ...
Dragan Copic +5 more
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Epigenetic Biomarkers in Cardiovascular Diseases
Frontiers in Genetics, 2019 Cardiovascular diseases are the number one cause of death worldwide and greatly impact quality of life and medical costs. Enormous effort has been made in research to obtain new tools for efficient and quick diagnosis and predicting the prognosis of ...
Carolina Soler-Botija +7 more
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Cardiac Regeneration in Model Organisms [PDF]
Current Treatment Options in Cardiovascular Medicine, 2014 Myocardial infarction is the most common cause of cardiac injury in humans and results in acute loss of large numbers of myocardial cells. Unfortunately, the mammalian heart is unable to replenish the cells that are lost following a myocardial infarction and an eventual progression to heart failure can often occur as a result.
Gamba, Laurent +2 more
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Advances in Epicardial Biology: Insights from Development, Regeneration, and Human Cardiac Organoids
The epicardium plays a pivotal role in heart development, regeneration, and disease response through its contributions to multiple cardiac lineages and its dynamic paracrine signaling.
Shasha Lyu +7 more
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Cell-Free Approaches and Therapeutic Biomolecules for Cardiac Regeneration
, 2021 In contrast with some adult human organs, such as liver or skin, the adult human heart shows very limited self-regeneration capacity, attributed to the negligible presence of resident cardiac stem cells or cardiac progenitors [...
Mariann Gyöngyösi
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Nature Communications, 2022 Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ...
Donghong Zhang +7 more
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Transcriptional Programs and Regeneration Enhancers Underlying Heart Regeneration
Journal of Cardiovascular Development and Disease, 2018 The heart plays the vital role of propelling blood to the entire body, which is essential to life. While maintaining heart function is critical, adult mammalian hearts poorly regenerate damaged cardiac tissue upon injury and form scar tissue instead ...
Ian J. Begeman, Junsu Kang
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Cardiac Regeneration: A Promising Future For Tissue Engineering and Cardiac Repair [PDF]
Cardiovascular diseases are the leading cause of human death worldwide. These diseases have detrimental effects on the heart, damaging the tissue and disrupting healthy heart function.
Patel, Krishay
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