Results 51 to 60 of about 87,451 (296)

Lessons learnt in the first year of an Australian pediatric cardio oncology clinic

Cardio-Oncology, 2023
Background Modern oncological therapies together with chemotherapy and radiotherapy have broadened the agents that can cause cardiac sequelae, which can manifest for pediatric oncology patients while on active treatment.
Claudia Toro, Ben Felmingham, Mangesh Jhadav, David S. Celermajer, Andre La Gerche, John O’Sullivan, Sanjeev Kumar, Marion K. Mateos, Joy Fulbright, Dinisha Govender, Lane Collier, Michael Cheung, David D. Eisenstat, Peter W. Lange, Julian Ayer, David A. Elliott, Rachel Conyers   +16 more
doaj   +1 more source

Metabolic Regulation of Cardiac Regeneration

Frontiers in Cardiovascular Medicine, 2022
The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure.
Xuewen Duan, Xingguang Liu, Zhenzhen Zhan   +2 more
openaire   +3 more sources

MicroRNAs in heart and circulation during physical exercise

Journal of Sport and Health Science, 2018
Exercise training is beneficial to the cardiovascular system. MicroRNAs (miRNAs, miRs) are a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of eukaryotic gene expression.
Lijun Wang, Yicheng Lv, Guoping Li, Junjie Xiao   +3 more
doaj   +1 more source

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

Nature Communications, 2021
Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic ...
Lukas S. Tombor, David John, Simone F. Glaser, Guillermo Luxán, Elvira Forte, Milena Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H. Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P. Harvey, Wesley T. Abplanalp, Stefanie Dimmeler   +23 more
doaj   +1 more source

Micromanaging cardiac regeneration: Targeted delivery of microRNAs for cardiac repair and regeneration

World Journal of Cardiology, 2016
The loss of cardiomyocytes during injury and disease can result in heart failure and sudden death, while the adult heart has a limited capacity for endogenous regeneration and repair. Current stem cell-based regenerative medicine approaches modestly improve cardiomyocyte survival, but offer neglectable cardiomyogenesis.
Kamps, Jan A.A.M., Krenning, Guido
openaire   +2 more sources

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Nature Communications, 2022
The benefit of regular exercise on the heart has been well documented but the role of RNA m6A modification in exercise-induced cardiac remodelling remains largely unknown.
Lijun Wang, Jiaqi Wang, Pujiao Yu, Jingyi Feng, Gui-e Xu, Xuan Zhao, Tianhui Wang, H. Immo Lehmann, Guoping Li, Joost P. G. Sluijter, Junjie Xiao   +10 more
doaj   +1 more source

Revealing Pathways of Cardiac Regeneration [PDF]

Circulation: Genomic and Precision Medicine, 2018
See Article by Adamowicz, Morgan, and Haubner et al Major cardiac injuries like a large myocardial infarction lead to systolic heart failure because of loss of cardiomyocytes. Unlike during embryonic development,1 adult mammalian cardiomyocytes have limited ability to proliferate and replenish the adult mammalian heart.
Vinícius, Bassaneze, Richard T, Lee
openaire   +2 more sources

Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes [PDF]

, 2003
Background - Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial
Dimmeler, S, Aicher, A, Popp, R, Urbich, C, Busse, R, Badorff, C, Brandes, RP, Fleming, I, Zeiher, AM, Rupp, S   +9 more
core   +1 more source

The Effect of Paracrine Factors Released by Irradiated Peripheral Blood Mononuclear Cells on Neutrophil Extracellular Trap Formation

Antioxidants, 2022
Neutrophil extracellular trap (NET)-formation represents an important defence mechanism for the rapid clearance of infections. However, exaggerated NET formation has been shown to negatively affect tissue-regeneration after injury.
Katharina Klas, Anna S. Ondracek, Thomas M. Hofbauer, Andreas Mangold, Karin Pfisterer, Maria Laggner, Dragan Copic, Martin Direder, Daniel Bormann, Hendrik Jan Ankersmit, Michael Mildner   +10 more
doaj   +1 more source

Cardiac Anisotropy, Regeneration, and Rhythm [PDF]

Circulation Research, 2014
With great interest, we read the commentary of Anderson et al1 on the recent publication of Chong et al2 about the large-scale use of human embryonic stem cell–derived cardiomyocytes to regenerate infarcted, nonhuman primate myocardium. In their commentary, they focus on the development of ventricular tachyarrhythmias after injection of large numbers ...
Pijnappels, D.A., Schalij, M.J., Atsma, D.E., Vries, A.A.F. de   +3 more
openaire   +3 more sources