Results 31 to 40 of about 158,981 (293)
The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring
Pharmaceutics, 2023 Hypertrophic scars can cause pain, movement restrictions, and reduction in the quality of life. Despite numerous options to treat hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood.
Vera Vorstandlechner +7 more
doaj +1 more source
Nature Communications, 2021 Mechanisms triggering hypertrophic scar formation remain poorly understood. Here the authors perform scRNA-seq on mature human hypertrophic scars and developing scars in mice to identify the serine proteases dipeptidyl-peptidase 4 and urokinase as key ...
Vera Vorstandlechner +12 more
doaj +1 more source
Circulation Research, 2017 Palliative surgery for congenital heart disease has allowed patients with previously lethal heart malformations to survive and, in most cases, to thrive. However, these procedures often place pressure and volume loads on the heart, and over time, these chronic loads can cause heart failure.
Francisco X, Galdos +5 more
openaire +3 more sources
Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b
Molecular Therapy: Nucleic Acids, 2021 The activation of the renin-angiotensin system (RAS) induced by increased angiotensin II (AngII) levels has been implicated in muscle atrophy, which is involved in the pathogenesis of congestive heart failure.
Jin Li +12 more
doaj +1 more source
Circulating microRNAs in Response to Exercise Training in Healthy Adults
Frontiers in Genetics, 2020 Circulating microRNAs (miRNAs, miRs) have great potential as cardiac biomarkers and they are also being explored for their roles in intercellular communication and gene expression regulation.
Qiulian Zhou +6 more
doaj +1 more source
New perspectives to repair a broken heart [PDF]
, 2009 The aim of cardiac cell therapy is to restore at least in part the functionality of the diseased or injured myocardium by the use of stem/ progenitor cells.
BARILE, Lucio +9 more
core +1 more source
Cardiac Regeneration: the Heart of the Issue [PDF]
Current Transplantation Reports, 2021 Abstract Purpose of Review The regenerative capacity of the heart is insufficient to compensate for the pathological loss of cardiomyocytes during a large injury, such as a myocardial infarction. Therapeutic options for patients after cardiac infarction are limited: treatment with drugs that only treat the symptoms or ...
Carotenuto, Felicia +2 more
openaire +3 more sources
Normal versus pathological cardiac fibroblast-derived extracellular matrix differentially modulates cardiosphere-derived cell paracrine properties and commitment [PDF]
, 2017 Human resident cardiac progenitor cells (CPCs) isolated as cardiosphere-derived cells (CDCs) are under clinical evaluation as a therapeutic product for cardiac regenerative medicine.
Angelini, Francesco +11 more
core +9 more sources
Analysis of Exosome Transfer in Mammalian Cells by Fluorescence Recovery after Photobleaching
Bio-Protocol, 2018 During the course of evolution, prokaryote and eukaryote cells have developed elegant and to some extent analogous strategies to communicate with each other and to adapt to their surrounding environment.
Hernán González-King +9 more
doaj +1 more source
npj Regenerative Medicine, 2023 Neonatal mouse heart can regenerate after left ventricle (LV) apical resection (AR). Since current AR rodent method is accomplished by resecting LV apex until exposure of LV chamber, it is relatively difficult to operate reproducibly. We aimed to develop
Yihua Bei +12 more
doaj +1 more source