Results 31 to 40 of about 1,204,541 (198)
MicroRNAs and Cardiac Regeneration [PDF]
Circulation Research, 2015 The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling by fibroblasts, resulting in the eventual deterioration of cardiac structure and function.
Conrad P, Hodgkinson +4 more
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Mechanisms of Cardiac Regeneration [PDF]
Developmental Cell, 2016 Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading cause of heart failure and death worldwide. Although all adult mammals appear to lack significant cardiac regeneration potential, some vertebrates can regenerate myocardium throughout life. In addition, new studies indicate that mammals
Uygur, Aysu, Lee, Richard T.
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miRNA in cardiac development and regeneration [PDF]
Cell Regeneration, 2021 Abstract Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of proliferation, making it impossible to regenerate the heart after injuries such as myocardial infarction.
Zhaohui Ouyang, Ke Wei
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Porcine Models of Heart Regeneration
, 2022 Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal ...
Katherine E. Yutzey +1 more
core +1 more source
Frontiers in Cardiovascular Medicine, 2020 Muscle atrophy is a common complication of heart failure. At present, there is no specific treatment to reverse the course of muscle atrophy. Exercise training, due to the safety and easy operation, is a recommended therapy for muscle atrophy induced by ...
Qi Liu +4 more
doaj +1 more source
npj Regenerative Medicine, 2023 Neonatal mouse heart can regenerate after left ventricle (LV) apical resection (AR). Since current AR rodent method is accomplished by resecting LV apex until exposure of LV chamber, it is relatively difficult to operate reproducibly. We aimed to develop
Yihua Bei +12 more
doaj +1 more source
Reprogramming for cardiac regeneration
Global Cardiology Science and Practice, 2014 Treatment of cardiovascular diseases remains challenging considering the limited regeneration capacity of the heart muscle. Developments of reprogramming strategies to create in vitro and in vivo cardiomyocytes have been the focus point of a considerable amount of research in the past decades. The choice of cells to employ, the state-of-the-art methods
Raynaud, Christophe Michel +5 more
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Scientific Reports, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the ...
Christine Bekos +12 more
doaj +1 more source
Frontiers in Physiology, 2018 Emerging evidence indicates the beneficial effects of physical exercise on human health, which depends on the intensity, training time, exercise type, environmental factors, and the personal health status.
Yongqin Li +8 more
doaj +1 more source
Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433
Frontiers in Genetics, 2019 Cardiac fibrosis is the pathological consequence of fibroblast proliferation and fibroblast-to-myofibroblast transition. As a new class of endogenous non-coding RNAs, circular RNAs (circRNAs) have been identified in many cardiovascular diseases including
Yujiao Zhu +6 more
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